Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SNTG2

contributors: - updated : 22-09-2006

HGNC name	syntrophin, gamma 2
HGNC id	13741

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p25      Physical location : 946.553 - 1.371.382
Genatlas name	dystrophin associated protein A1
Synonym name	syntrophin 5
Synonym symbol(s)	DAPA1G1, SYN5, G2SYN, STG2

DNA

TYPE	functioning gene
STRUCTURE	317.00 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           brain diencephalon hypothalamus       brain forebrain cerebral cortex       nerve cranial nerve       Reproductive male system testis       Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular         Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one pleckstrin homology (PH) domains by the C-terminus
	a PDZ (PSD95/disc large/ZO1) domain, directly interacting with the C terminus of SCN5A
	N-terminal part, including the PDZ domain, and the C-terminal half involved in the binding to NLGNs

HOMOLOGY

interspecies

homolog to C.Elegans F27D9.8

Homologene

FAMILY

syntrophin family

CATEGORY

adaptor , structural protein

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	cytoplasmic side of sarcolemma, perikaryon, proximal part of the neuron process

basic FUNCTION	adapter protein binding to and probably organizing the subcellular localization of a variety of proteins
	essential Na(+) channel-interacting protein required for the full expression of the Na(+) current
	play a key role as scaffolding proteins in both neuromuscular junctions and the central nervous system, where they interact with dystrophin and dystrobrevin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

dystrophin complex

INTERACTION

DNA

RNA

small molecule

protein	binding the C terminal region of dystrophin and related proteins
	interacting with SCN5A to determines mechanosensitivity and current availability
	binding NLGN4X and NLGN4Y, NLGN3 (binding is influenced by autism-related mutations)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to autism (through interactions between neuroligins and SNTG2 at the inhibitory synapse)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS