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FLASH GENE
Symbol SNIP1 contributors: mct - updated : 02-06-2006
HGNC name Smad nuclear interacting protein 1
HGNC id 30587
Location 1p34.3      Physical location : 38.002.144 - 38.019.903
Genatlas name Smad nuclear interacting protein
Synonym symbol(s) FLJ12553
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 17.76 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LSM10 1p34.3 U7 snRNP-specific Sm-like protein LSM10 NOR1 1p34.3 oxidored-nitro domain-containing protein MRPS15 1p35-p34.1 mitochondrial ribosomal protein S15 CSF3R 1p34.2-p34.1 colony stimulating factor 3 receptor (granulocyte) GRIK3 1p34.1 glutamate receptor, ionotropic, kainate 3 FLJ23231 1p34.2 hypothetical protein FLJ23231 FLJ11730 1p35.3-p33 hypothetical protein FLJ11730 SNIP1 1p34.2 Smad nuclear interacting protein DNALI1 1p35.1 dynein, axonemal, light intermediate polypeptide 1 HUMAUANTIG 1p34.2 nucleolar GTPase FLJ40906 1p34.2 hypothetical protein FLJ40906 FLJ20508 1p34.2 hypothetical protein FLJ20508 CDCA8 1p34.2 cell division cycle associated 8 FLJ33655 1p34.2 hypothetical protein FLJ33655 LOC391026 1 similar to actinin, alpha 4 LOC391027 1 similar to chromosome 14 open reading frame 138 FLJ31434 1p34.2 hypothetical protein FLJ31434 FLJ45459 1p34.2 FLJ45459 protein SF3A3 1p34.1 splicing factor 3a, subunit 3, 60kDa FHL3 1p34.2-p32.3 four and a half LIM domains 3 CGI-94 1p34.2 comparative gene identification transcript 94 POU3F1 1p34.1 POU domain, class 3, transcription factor 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   predominantly
Lymphoid/Immunelymph node   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal bipartite nuclear localization signal
  • a C-terminal forkhead-associated (FHA) domain that regulates gene expression through interactions with multiple transcriptional regulators
  • HOMOLOGY
    interspecies ortholog to murine Snip1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • down-regulating NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding
  • may regulate access of transcription factors to the coactivators p300 and CBP in select cells
  • may regulate the pattern of gene expression in embryogenesis
  • acting as a regulator of the cell cycle and cyclin D1 expression
  • functions as an important regulator of c-Myc activity, binding the N terminus of c-Myc through its own C terminus
  • might be an important modulator of c-Myc activity in carcinogenesis
  • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MADH4
  • CREBBP/EP300
  • ADH1/OAZ1/PSMB4 complex
  • associates with c-Myc, a key regulator of cell proliferation and transformation
  • cell & other
    REGULATION
    induced by induced upon serum stimulation immediately prior to cyclin D1 expression
    Other degraded by the proteasome upon binding to the ADH1/OAZ1/PSMB4 complex
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS