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FLASH GENE
Symbol SNF8 contributors: npt/ - updated : 29-10-2012
HGNC name SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
HGNC id 17028
Location 17q21.32      Physical location : 47.007.460 - 47.022.154
Synonym name
  • EAP30 subunit of ELL complex
  • sucrose non-fermenting 8
  • ESCRT-II complex subunit VPS22
  • ELL-associated protein of 30 kDa
  • vacuolar-sorting protein SNF8
  • Synonym symbol(s) Dot3, EAP30, VPS22
    DNA
    TYPE functioning gene
    STRUCTURE 14.69 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1226 28.9 258 - 1999 10419521
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemuterus  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain involved in the formation of a heterotetrameric ESCRTII complex
  • HOMOLOGY
    Homologene
    FAMILY
  • SNF8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • detected on the limiting membrane of multivesicular endosomes
  • basic FUNCTION
  • required for efficient derepression of glucose-repressed genes
  • important role in ligand-induced EGFR and CXCR4 turnover, suggesting that termination of EGF signaling occurs prior to ESCRT-II engagement
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45
  • component of the ESCRT-II complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the N-terminal half of RILP
  • RILP interacts with SNF8 and VPS36 of ESCRT-II to mediate their membrane recruitment
  • MCM2 binds to SNF8 and MCM2 competes with ELL for binding to SNF8 thus potentially modulating the stability of Holo-ELL complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS