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FLASH GENE

Symbol

SND1

contributors: mct/npt/pgu - updated : 16-10-2014

HGNC name	staphylococcal nuclease and tudor domain containing 1
HGNC id	30646

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q32.1      Physical location : 127.292.201 - 127.732.658
Synonym name	EBNA2 coactivator p100
	tudor-SN 11
	Epstein-Barr virus nuclear antigen 2 (EBNA2)-coactivator, staphylococcal nuclease domain
	p100 EBNA2 co-activator
Synonym symbol(s)	P100, TDRD11, TUDOR-sn

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	440.46 kb     24 Exon(s)

regulatory sequence	Promoter (CAAT box)
	cytosine-phosphate-guanine/HTF
	Binding site   transcription factor
text structure	3808 bp sequence corresponding to the human SND1 gene promoter
	lacks the typical TATA-box element and contains a CpG island with several Sp1 binding sites at the 3prime end, and a highly conserved 300 bp segment with two inverted CCAAT boxes that bind NFY, in addition to NFKB sites and other cis-regulatory elements

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D7S686 - SND1 - D7S530 - qter
Authors	Liénard (00)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014390 24 - 3522 NP_055205 - 910 - 2008 18453631

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two potential nuclear localization signals (NLS) and a Tudor domain, embedded in a fifth SN domain
	four tandem repeats of staphylococcal nuclease-like domains (SN1-SN4), functioning as a clamp to capture RNA substrates
	C-terminal SN domain (SN5)

HOMOLOGY

Homologene

FAMILY

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus
text	nuclear localization signal
	is a novel component of stress granules

basic FUNCTION	coactivating gene expression regulated by the Epstein-Barr virus nuclear antigen 2 acidic domain
	stimulates IL4-dependent transcription by mediating interaction between STAT6 and CREBBP and recruiting chromatin modifying activities to STAT6-responsive promoters
	involved in the degradation of hyper-edited inosine-containing microRNA precursors, thus linking the pathways of RNA interference and editing
	vital transcription regulator that increases gene transcription by forming a physical bridge between promoter-specific activators and the basal transcription machinery
	having distinct roles in transcription and splicing
	function as a transcriptional co-activator for several transcription factors
	having dual function regulator of gene expression that participates via distinct domains in both transcription and splicing
	promotes angiogenesis by augmenting the production of angiogenin and CXCL16
	is a major nodal point in the carcinogenic network
	SND1 promotes the inclusion of CD44 variable exons by recruiting KHDRBS1 and spliceosomal components on CD44 pre-mRNA
	is a novel regulator of alternative splicing that promotes Prostate cancer cell growth and survival
	modulates the kinetics of AGTR1-3prime UTR granule formation, which provides an additional biological role of SND1 in RNA metabolism during stress

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the small interfering RNA and microRNA and the RNA-induced silencing complex (RISC)
	component of RNA induced silencing complex of the siRNA pathway
	complexing with MTDH and dual role of the MTDH-SND1 complex in suppressing the apoptotic response and promoting breast cancer development

INTERACTION

DNA

RNA

small molecule

protein	interacts with U small nuclear ribonucleoprotein (snRNP) complexes
	SND1 physiologically interact with G3BP1, which is the marker and effector of stress granules
	binds PIWIL1 in an arginine methylation-dependent manner with a preference for symmetrically dimethylated arginine
	SND1 is a novel MTDH-interacting protein and it is a functionally and clinically significant mediator of metastasis
	interacts with spliceosomal small nuclear ribonucleoproteins via its tudor domain and accelerates the kinetics of spliceosome assembly and splicing activity
	ANG and CXCL16 are required for SND1-induced angiogenesis
	is a new target gene for NFKB, SP1 and NFY transcription factors
	interaction of KHDRBS1 with SND1
	increases angiotensin II type 1 receptor (AGTR1) levels by increasing AGTR1 mRNA stability

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in recurrent androgen-insensitive prostate cancer tissues tumoral     --over   in colon cancers (SND1 may thus occur at a very early stage in colon carcinogenesis and contribute to the posttranscriptional regulation of key players in colon cancer development, including APC and beta-catenin) tumoral     --over   in multiple cancers, including hepatocellular carcinoma (HCC)

Susceptibility

Variant & Polymorphism SNP

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate promising prostate cancer biomarker and therapeutic target cancer digestive liver targeted inhibition of SND1 could be an effective way to counteract hepatocellular carcinoma

ANIMAL & CELL MODELS