Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SNAPIN contributors: mct/npt/pgu - updated : 16-04-2014
HGNC name SNAP-associated protein
HGNC id 17145
Location 1q21.3      Physical location : 153.631.144 - 153.634.325
Synonym name
  • snapin
  • SNARE associated protein snapin
  • snapin
  • SNAP-25-binding protein
  • synaptosomal-associated protein 25-binding protein
  • Synonym symbol(s) SNAPAP, SNAP25BP
    DNA
    TYPE functioning gene
    STRUCTURE 3.18 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1047 14 136 - 2003 12659861
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Lymphoid/Immunetonsils   highly
    Nervousbrain   specific
    Reproductivemale systemprostate   
     male systemtestis   
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, perinatal, growth/childhood
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • a N-terminal hydrophobic segment characteristic of a transmembrane domain
  • a coiled-coil C-terminal helical domain containing the SNAP23-binding site, responsible for protein-protein interaction and could enable SNAPIN to be an adaptor of PUM2 and NANOS1, binding other factors to regulate translation in the development of the human germ cells
  • HOMOLOGY
    interspecies homolog to rattus LOC295217
    homolog to murine Snapap
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • peripheral membrane-bound pools in adipocytes
  • in human testis, SNAPIN co-localizes with PUM2 and NANOS1 in prenatal and also in spermatogenic germ cells of the adult
  • basic FUNCTION
  • SNARE binding activity
  • playing a general role in SNARE-mediated vesicle fusion events in non-neuronal cells in addition to its participation in Ca2+-regulated neurosecretion
  • functioning as a regulator of an important cAMP synthesis enzyme in the brain
  • regulates dendrite number in developing neurons by modulating cypin-promoted microtubule assembly
  • probable targets for the amplification mechanism and may therefore be involved, together or separately, in the development or progression of Hepatocellular carcinoma
  • promote the maturation/priming of synaptic vesicles (SVs) by interacting with components of the SNARE complex
  • plays an extra role in mammals which is germ cell specific
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a ubiquitously expressed multisubunit protein complex required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SNAP25
  • ADCY6 interacting protein
  • binds to cypin's (GDA) CRMP homology domain, which is where tubulin binds (competes with tubulin for binding to cypin, resulting in decreased microtubule assembly)
  • robust interaction with wild type and mutant torsinA (TOR1A)
  • binding partner of dysbindin-1 in the brain (function of dysbindin-1 in presynaptic, postsynaptic and microtubule locations may all be related to known functions of snapin)
  • interaction partner of CSNK1D (possible function for CKSNK1D in modulating snapin specific functions)
  • interacting with PUM2 (interacts with SNAPIN, a modulator of SNARE complex assembly, which is involved in vesicle trafficking
  • interacts additionally with NANOS1 protein
  • interacting with the C terminus of ADRA1A (augments ADRA1A-operated calcium influx through TRPC6)
  • EHD1 binds to the C terminus of SNAPIN via its C terminus EH domain
  • ADCY6, an enzyme which catalyzes cAMP synthesis, regulates neurite outgrowth by direct interaction with a binding protein (SNAPIN) of SNAP25 at the N terminus of ADCY6 (AC6-N)
  • specifically binds to SNAPIN and this interaction effectively facilitates endosomal maturation without affecting autophagic cargo degradation
  • RNF13 directly interacted with SNAPIN, a SNAP-25-interacting protein
  • SNAPIN, a SNAP25 interacting protein, interacts with LRRK2
  • LRRK2 may regulate neurotransmitter release via control of SNAPIN function by inhibitory phosphorylation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS