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FLASH GENE
Symbol SNAPC4 contributors: mct/npt - updated : 16-01-2019
HGNC name small nuclear RNA activating complex, polypeptide 4, 190kDa
HGNC id 11137
Location 9q34.3      Physical location : 139.270.029 - 139.292.889
Synonym name
  • PSE-binding factor subunit alpha
  • PTF subunit alpha
  • proximal sequence element-binding transcription factor subunit alpha
  • Synonym symbol(s) SNAP190, PTFALPHA, FLJ13451
    DNA
    TYPE functioning gene
    STRUCTURE 24.65 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CAMSAP1 9q34.3 calmodulin regulated spectrin-associated protein 1 LOC389805 9 similar to 9530003A05 protein GBDR1 9q34.1-q34.3 similar to 9530003A05 protein BTBD14A 9q34.3 BTB (POZ) domain containing 14A LOC392400 9 similar to F4N2.10 LOC389806 9 hypothetical gene supported by BC009060 LOC389807 9 LOC389807 LOC389808 9 LOC389808 LOC389809 9 LOC389809 LHX3 9q34.3 LIM homeobox protein 3 QSCN6L1 9q34.3 quiescin Q6-like 1 AGS3 9q34.3 activator of G-protein signaling 3 LOC389810 9 LOC389810 CARD9 9q34.3 caspase recruitment domain family, member 9 SNAPC4 9q34.2-q34.3 small nuclear RNA activating complex, polypeptide 4, 190kDa SDCCAG3 9q34.3 serologically defined colon cancer antigen 3 PMPCA 9q34.3 peptidase (mitochondrial processing) alpha INPP5E 9q34.3 inositol polyphosphate-5-phosphatase, 72kDa KIAA0310 9q34.1 inositol polyphosphate-5-phosphatase, 72kDa FLJ36779 9q34.3 hypothetical protein FLJ36779 NOTCH1 9q34.3 Notch homolog 1, translocation-associated (Drosophila) LOC389811 9 similar to HSPC324 EGFL7 9q34.3 EGF-like-domain, multiple 7 AGPAT2 9q34.3 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) MGC20262 9q34.3 hypothetical protein MGC20262 MGC16037 9q34.3 hypothetical protein MGC16037 LCN6 9q34.3 lipocalin 6 LOC138307 LOC389812 LOC392401 9 similar to vacuolar H(+)-ATPase subunit; V-ATPase subunit; M16 MGC14141 9q34.3 hypothetical protein MGC14141 MGC15438 9q34.3 hypothetical protein MGC15438 FLJ10101 9q34.3 FLJ10101 protein LOC389813 9 similar to ENSANGP00000006371
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 4665 159 1469 - 2003 12621023
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousnerve   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five Myb-like binding domains
  • an unusual Myb DNA binding domain consisting of four complete repeats (Ra to Rd) and a half repeat (Rh)
  • SWI3, ADA2, N-COR and TF3B DNA binding domains
  • arginine and serine rich regions
  • a C terminal leucine zipper-like motif, and C-terminal half of SNAPC4 can interact with DNA-bound transcription activator POU2F1
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to C.elegans gei-11
    Homologene
    FAMILY
  • SNAPC gene family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • required for both RNA polymerase II and III transcription of snRNA
  • initiating basal levels of transcription
  • involved in direct recognition of the proximal sequence elements and is a target for the POU2F1 activator
  • forms the backbone of the complex and binds three of the four remaining subunits through two main regions as follows : a region within the N-terminal third binds SNAPC5 and SNAPC1, whereas a region close to the C terminus of the protein binds SNAPC2 (SNAPC3 joins the complex through contacts with SNAPC1)
  • SNAPC4 occupancy peaked prior to the transcription start site, where it could contribute to the recruitment of the general transcription machinery
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text snRNA transcription
    PATHWAY
    metabolism
    signaling
    a component
  • largest subunit of the snRNA-activating protein complex (SNAPc)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to DNA-bound transcription activator POU2F1 and SNAPC2, but not with SNAPC1 or SNAPC3
  • cell & other
    REGULATION
    Other phosphorylation of the N-terminal half at two regions (amino acids 20-63 and 514-545) that each contain multiple CK2 consensus sites (inhibits both SNAP(C) DNA binding and U6 transcription activity)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    leads to an accumulation of cells with a G0/G1 DNA content
    Susceptibility to ankylosing spondylitis (AS)
    Variant & Polymorphism SNP
  • SNP rs11145835 in 9q34.3 that harbors CARD9 and SNAPC4 is associated with AS
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS