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FLASH GENE
Symbol SMTNL1 contributors: mct - updated : 08-10-2011
HGNC name smoothelin-like 1
HGNC id 32394
Location 11q12.1      Physical location : 57.310.113 - 57.317.747
Synonym name calponin homology-associated smooth muscle
Synonym symbol(s) CHASM
DNA
TYPE functioning gene
STRUCTURE 7.63 kb     7 Exon(s)
regulatory sequence Promoter
text structure
  • the transcriptional start site (TSS) lays -44 bp from the translational start codon and a TATA-box motif at -75 bp was conserved amongst all mammalian Smtnl1 promoters
  • a single Smtnl1 transcription start site was identified in both skeletal and intestinal smooth muscle
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1649 - 494 - 2004 15327999
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
     mouthtongue   
     pharynx    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  moderately Homo sapiens
    Muscularstriatumskeletal highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal unfolded region (AA 1361) with minimal sequence similarity to the other smoothelin proteins
  • a actin-binding domain
  • two EF-hand domains
  • four spectrin repeats
  • a C-terminal, type-2 calponin homology (CH) domain (AA 361459) with a calmodulin (CaM)-binding IQ-motif, having similarity within a tropomyosin-binding domain (TBD) of smoothelin necessary for the localization of the protein to actin-containing filaments
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine calponin homology-associated smooth muscle protein
    Homologene
    FAMILY
  • smoothelin protein family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text intracellular localization to filamentous structures was dependent on the CH domain
    basic FUNCTION
  • eliciting Ca2+ desensitization in smooth muscle
  • playing a roles in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity
  • able to modulate the contractile activity of both smooth and skeletal muscle
  • having a unique position to influence thin-filament structure as well as Ca2+-regulated contraction
  • plays a role in promoting relaxation as well as adaptive responses to exercise, pregnancy and sexual development in smooth and skeletal muscle
  • possible restrictive control of its expression in non-muscle cells
  • plays a major role in pregnancy to promote adaptive responses in USM (uterine smooth muscle) and this process is specifically mediated through interactions of SMTNL1 with PGR
  • key player in USM plasticity mediated through the sex-related hormones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    conserved pathway in which sexual development and pregnancy mediate smooth and striated muscle adaptations through SMTNL1 and PPP1R12A
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can bind to tropomyosin, and the CH domain was important for the interaction
  • PP1R12A is target gene of SMTNL1 in smooth and striated muscles
  • directly and specifically binds PGR and suppresses its transcriptional activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS