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FLASH GENE
Symbol SMOX contributors: - updated : 28-09-2004
HGNC name spermine oxidase
HGNC id 15862
Location 20p13      Physical location : 4.129.449 - 4.168.369
Synonym name
  • chromosome 20 open reading frame 16
  • flavine containing amine oxidase
  • polyamine oxidase
  • flavine-containing spermine oxidase
  • putative cyclin G1 interacting protein
  • Synonym symbol(s) PAO, SMO, PAOh1, MGC1010, C20orf16
    DNA
    TYPE functioning gene
    STRUCTURE 38.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2203 61.9 555 placenta, non small-cell lung carcinoma, breast cancer, colon cancer, prostate cancer, hepatoma Wang
    the longest transcript, variants 1 and 5 both encode the same isoform
    - splicing 2044 - 502 placenta, non small-cell lung carcinoma Murray-Stewart
    lacking an in-frame segment of the coding region compared to variant 1
    - splicing 1108 - 190 placenta, non small-cell lung carcinoma Murray-Stewart
    lacking an in-frame segment of the coding region compared to variant 1
    - - 2134 - 532 placenta, non small-cell lung carcinoma Murray-Stewart
    having multiple differences in the coding region but maintaining the reading frame compared to variant 1
    - splicing 2291 61.9 555 placenta, non small-cell lung carcinoma Murray-Stewart
    differing in the 5' UTR compared to variant 1, variants 1 and 5 encode the same isoform
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated FlavoP
    HOMOLOGY
    interspecies homolog to rattus Rn 53620
    homolog to murine Smox-pending
    homolog to frog XI.1474
    homolog to Drosophila CG8032
    homolog to zebrafish Dr.11707
    Homologene
    FAMILY
    CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalysing oxidation of polyamine, spermine but also spermidin and N1 acetamide spermidine with production of spermidine (putrescine)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    polyamine catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    FAD
    protein
    cell & other
    REGULATION
    induced by cytotoxic polyamine analogues
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS