basic FUNCTION
| necessary for spliceosome assembly and nuclear mRNA splicing, by entering the pre-spliceosome in association with 17S U2 snRNP and mediating the assembly of the mature spliceosome |
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essential splicing factor, U2 snRNP-associated protein, facilitating the recruitment of the [U4/U6.U5] tri-snRNP to the pre-spliceosome (Meister 2001) |
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inducing apoptosis in a dose-dependent manner |
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have the potential to mediate the addition of the tri-snRNP to the prespliceosome (Little 2008) |
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SPF30 and its partner-interacting domains are not conserved in yeast, suggesting this interaction network may play an important role in the complex splicing observed in higher eukaryotes (Little 2008) |
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is a pre-mRNA splicing factor harboring a Tudor domain in its central region, which regulates various cellular events by binding to dimethylarginine-modified proteins |
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SMNDC1 collaborates with the MTREX-exosome machinery to play a functional role in multiple RNA metabolic pathways, some of which may be regulated by the ATP hydrolysis of NVL |