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FLASH GENE
Symbol SMG7 contributors: mct - updated : 06-02-2010
HGNC name Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
HGNC id 16792
Location 1q25.3      Physical location : 183.441.505 - 183.523.327
Synonym name
  • chromosome 1 open reading frame 16
  • KIAA0250 gene product
  • EST1 telomerase component homolog C (S. cerevisiae)"
  • EST1-like protein C
  • breast cancer-associated antigen SGA-56M
  • ever shorter telomeres 1C
  • Synonym symbol(s) KIAA0250, SMG-7, C1orf16, EST1C, SGA56M, FLJ23717, EST1
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 81.69 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 splicing 5846 127.3 1137 - Yamashita, Ohnishi, Fukuhara (2005)
    22 splicing 5708 - 1091 - Yamashita, Ohnishi, Fukuhara (2005)
    21 splicing 5676 - 1049 - Ohnishi, Fukuhara (2005)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two TPR repeats
  • 14-3-3-like domain
  • HOMOLOGY
    interspecies ortholog to murine Smg7
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • acting as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation
  • required for telomere DNA maintenance (de Zwaan 2009)
  • upregulates the telomerase DNA extension activity independent of DNA interactions (de Zwaan 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA associates with the DNA during telomerase-mediated DNA lengthening (de Zwaan 2009)
    RNA
    small molecule
    protein
  • interaction with CDC13, critical for modulating telomerase DNA extension activity (de Zwaan 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS