basic FUNCTION
| involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1 |
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acting as a serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways |
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functioning in NMD by phosphorylating the regulator of nonsense transcripts 1 protein |
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may activate PRKCI |
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may function in telomere maintenance, responses to hypoxia, and TNFA–induced apoptosis |
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can phosphorylate TP53/p53 and is required for optimal TP53/p53 activation after cellular exposure to genotoxic stress |
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has a critical role in the degradation of premature termination codon (PTC)–containing transcripts mediated by the nonsense-mediated mRNA decay (NMD) pathway |
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recognizing the substrate consensus sequence [ST]-Q |
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playing an important role in cell survival during TNFalpha-induced stress |
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plays dual roles in mRNA surveillance and genotoxic stress response pathways in cells |
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proximal regulator of DNA damage signaling and the G(1) checkpoint is tightly regulated during prolonged oxidative stress by both phosphatidylinositol 3-kinase-like kinases-dependent synthesis and proteolysis of CDKN1A  |
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activates the essential nonsense-mediated mRNA decay (NMD) factor UPF1  |
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is a large kinase essential to nonsense-mediated mRNA decay (NMD) that phosphorylates UPF1, which seems to be the definitive signal triggering mRNA decay  |
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SMG1 and MAP3K14 function as critical repressors of Smac mimetic compounds-mediated apoptosis by potentially converging on the regulation of CFLAR metabolism  |
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activates TPp53 in response to DNA double-strand breaks independent of the RNA surveillance proteins UPF1 or UPF2  |
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plays a central role in the process of stress granule formation  |
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role in nonsense-mediated decay as well as suggested roles in the DNA damage response, resistance to oxidative stress, regulation of hypoxic responses, and apoptosis  |
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participates likely in the regulation of inflammation and cancer development, and is a cancer susceptibility gene that may play a role in the pathogenesis of both lung and hematopoietic cancers  |