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FLASH GENE
Symbol SMC6 contributors: mct - updated : 06-12-2017
HGNC name structural maintenance of chromosomes 6
HGNC id 20466
Location 2p24.2      Physical location : 17.845.079 - 17.935.096
Synonym name
  • SMC6 protein
  • SMC6 structural maintenance of chromosomes 6-like 1 (yeast)
  • Synonym symbol(s) FLJ22116, FLJ35534, SMC6L1
    DNA
    TYPE functioning gene
    STRUCTURE 90.02 kb     28 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 5275 - 1091 - -
    27 - 5188 - 1091 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    Digestiveliver    
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary   
     male systemtestis  highly
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an IQ domain
  • a myosin head-like domain
  • HOMOLOGY
    Homologene
    FAMILY
  • SMC family
  • RAD18 subfamily
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in chromosome segregation
  • acting in a DNA repair pathway for removal of uv-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage
  • involved in muscle contraction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the SMC5/6 complex (Chen 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with ubiquitin ligase RAD6 protein, forming a complex with ubiquitin ligase activity
  • interacting with SMC5 (hSMC5/6 complex promotes DNA repair and suggest a novel strategy to improve the efficiency of gene targeting in somatic cells)
  • SMC5/SMC6 complex physically interacts with TOP2A, and the SMC5/6 complex functions in resolving TOP2A-mediated DSB-repair intermediates generated during replication
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS