SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| intracellular,nucleus,chromatin/chromosome
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| intracellular,nucleus,nucleolus
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text
| nuclear speckles at interphase |
basic FUNCTION
| invoved in mitotic chromosome segregation |
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condensin gene (SMC2, SMC4) alteration might play a role in genome instability, which accelerates the accumulation of other gene alterations in pyothorax-associated lymphoma |
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unique role for condensin complexes in interphase chromatin compaction in embryonic stem cells |
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SMC2 (CAP-E) and SMC4 (CAP-C), plays a critical role in the formation of higher order chromosome structures during mitosis |
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SMC2 also transcriptionally regulates DNA damage response genes in cooperation with MYCN |
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novel functions of SMC2 in DNA damage response |
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SMC2, SMC4 plays a central role in organizing and compacting chromosomes, which determines DNA-binding activity and gene expression |