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FLASH GENE
Symbol SMC1B contributors: npt/ - updated : 10-02-2006
HGNC name structural maintenance of chromosomes 1B
HGNC id 11112
Location 22q13.31      Physical location : 45.739.946 - 45.809.500
Synonym name
  • mitosis-specific chromosome segregation protein like protein beta
  • SMC1 structural maintenance of chromosomes 1-like 2 (yeast)
  • SMC1beta protein
  • Synonym symbol(s) SMC1BETA, SMC1L2, bK268H5, FLJ43748
    DNA
    TYPE functioning gene
    STRUCTURE 69.56 kb     25 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 4266 144 1235 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunelymph node   moderately
    Reproductivemale systemtestis  moderately
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period ageing
    cell cycle     cell cycle
    Text exhibiting age-dependent defects in meiosis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal NTP-binding site
  • a central coiled-coil region
  • a unique C terminus
  • a flexible hinge domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast-like 2 smc1
    ortholog to rattus Smc1l2_predicted
    ortholog to murine Smc1l2
    Homologene
    FAMILY
  • SMC family
  • SMC1 subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,centromere
    text axial elements of synaptonemal complexion prephase 1
    basic FUNCTION
  • structural maintenance of chromosomes and cohesion between sister centromeres until anaphase 2
  • in addition to its role in sister chromatid cohesion, determines meiotic chromatin loop organization (Novak 2008)
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with SMC3 (CSPG6)
  • component of synaptonemal complexes in prophase I
  • component of the cohesin complex containing CSPG6, RAD21 and SA1, SA2 yeast ortholog and regulating a novel prophase pathway
  • forming a V- shaped heterodimer
  • the two heads of the heterodimer are then connected by different ends of the cleavable RAD21 or REC8 protein, forming a ring structure
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP/GTP
  • protein
  • SMC3 (CSPG6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS