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FLASH GENE
Symbol SMARCD3 contributors: mct - updated : 20-09-2023
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
HGNC id 11108
Location 7q36.1      Physical location : 150.936.059 - 150.974.231
Synonym name
  • BRG1 (brm/SWI2-related gene 1) associated factor 60C
  • Brahma-associated factor 60c
  • chromatin remodeling complex BRG1-associated factor 60C
    • Synonym symbol(s) BAF60C, CRACD3, Rsc6p, MGC111010
    DNA
    TYPE functioning gene
    STRUCTURE 38.17 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1689 - 470 - 2007 17210915
    V1 or BAF60c1
    13 - 1700 - 483 - 2007 17210915
    V3 or BAF60c2
    14 - 1728 - 470 - 2007 17210915
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
     parathyroid   highly
    Nervousnervecranial nerve  highly
     nerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast SWP73
    homolog to yeast S.cerevisiae SWI/SNF,Rsc6p
    Homologene
    FAMILY SWI/SNF family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    text matrix associated
    basic FUNCTION
  • actin-dependent regulator of chromatin structure
  • playing an essential role for function of BAF chromatin remodelling complexes in heart development
  • required for Notch-dependent transcriptional activation and functions to stabilize interactions between activated Notch and its DNA-binding partner
  • playing a critical role in Notch-dependent transcription and Left-Right asymmetry
  • is a component of the neural progenitor-specific BAF complex in developing retina
  • is a necessary co-regulator of TGFB1 mediated induction of Smooth muscle cells (SMCs) genes
  • is important for TGFB1-mediated commitment of primitive stem cells (rMAPCs) to SMCs
  • is a specific chromatin remodeling component for lipogenic gene transcription in liver
  • promotes lipogenesis and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin
  • transcriptional cofactor enriched in fast-twitch muscle, promoting a switch from oxidative to glycolytic myofiber type through DEPTOR-mediated AKT1 activation
  • required for maintaining glycolytic capacity in adult skeletal muscle
  • SMARCD3-SIX4 transcriptional complex inducing DEPTOR and mediating activation of AKT1 and glycolytic metabolism by SMARCD3 in a cell-autonomous manner
  • epigenetically regulates EMT by activating WNT signaling pathways
  • its expression and expression of DEPTOR was downregulated in skeletal muscle in obesity, accompanied by extracellular signal-related kinase (ERK) activation
  • functional redundancy between SMARCD1 and SMARCD3 in maintaining oxidative and glycolytic metabolism in skeletal myofibers and exercise endurance
  • SMARCD1, D2, D3 proteins are involved in the regulation of numerous hormone-dependent AR-driven genes, and play an important, yet paradoxical, role in prostate carcinogenesis
  • SMARCD3 acts with FOXA1 to control lipid and fatty acid metabolism, programs associated with therapy resistance and poor prognosis in cancer
  • SMARCD3 is an epigenetic modulator responsible for establishing the metabolic landscape in aggressive pancreatic cancer cells and a potential target for new therapies
    • CELLULAR PROCESS nucleotide, chromatin organization
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • SMARCD3/DEPTOR pathway is a target of proinflammatory signaling in skeletal muscle that may link meta-inflammation to skeletal myofiber metabolism and insulin resistance
    • a component subunit of the BAF (BRG1/brm-associated factor) complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • facilitates MYOD1 binding to target genes and marks the chromatin for signal-dependent recruitment of the SWI/SNF core to muscle genes
  • transient inhibition of NODAL by CER1 induces Brahma-associated factor 60c (SMARCD3)
  • APLNR controls a regulatory CER1-SMARCD3 pathway in pluripotent stem cell cardiomyogenesis
  • while GATA4 and SMARCD3 are key inducers of myocardial differentiation, TBX5 is essential for the ability of cardiac cells to contract
  • SMARCD3 and SMARCC2 are required for proper BAF complex composition, and SMARCC2 loss leads to retention of SMARCA4 at cardiac precursors (CPs)-specific sites
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS