basic FUNCTION
| actin-dependent regulator of chromatin structure |
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SMARCA4, SMARCD2, DPF2 are required for the expression of haematopoietic stem cell associated genes but in contrast to previous results obtained in mouse cells, the three proteins are not required for the expression of MYC regulated genes |
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links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci |
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is a critical regulator of myeloid differentiation |
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controls early steps in the differentiation of myeloid-erythroid progenitor cells |
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is a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia |
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conserved role specifically for the SMARCD2 subunit in granulopoiesis |
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SMARCD1, D2, D3 proteins are involved in the regulation of numerous hormone-dependent AR-driven genes, and play an important, yet paradoxical, role in prostate carcinogenesis |