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FLASH GENE
Symbol SMAGP contributors: npt/mct - updated : 20/11/2008
Location 12q13.13      Physical location : 51.639.132 - 51.664.202
Genatlas name small trans-membrane and glycosylated protein
Synonym name
  • small cell adhesion glycoprotein
  • LOC57228 protein
  • Synonym symbol(s) LOC57228, MGC149453, MGC149454
    DNA
    TYPE functioning gene
    STRUCTURE 25.07 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1087 11 97 - Ota (2004)
    4 - 1076 11 97 - Ota (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     stomach   highly
    Reproductivefemale systemplacenta  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • binding domains for the protein 4.1
  • the PDZ domain of MAGUK proteins
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • involved in a scaffolding protein complex, and therefore participate in the epithelium organization or in subsequent functions
  • strongly promotes tumor progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast, colon and lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS