basic FUNCTION
| sequence specific transcriptional activator |
|
critical mediator of TGFB and BMP signaling pathways |
|
corepressor for estrogen receptor (ER) alpha |
|
can repress the SMAD3-enhanced ER alpha (ESR1)transactivation in a dose dependent-manner |
|
central intracellular signal transducer for transforming growth factor-beta (TGF-beta) signaling |
|
involved in carcinogenesis mainly of the pancreas and colon |
|
in colon and pancreatic tumor cells, functioning as a positive transcriptional regulator of all three genes encoding LAMA5 |
|
having function in the control of an essential basement membrane component |
|
having activity in the developing endothelial cells essential for blood vessel remodeling, maturation, and integrity |
|
required for the development and maintenance of the lens in addition to the proper development of the cornea, eyelids, and retina |
|
may affect lens survival and function by controlling lens differentiation |
|
likely functions as a signaling mediator downstream of Activinbeta B in regulating actin stress fiber assembly and eyelid epithelial movement |
|
key regulator of prostate cancer progression |
|
GATA4 and SMAD4 cooperatively activated the ID2 promoter |
|
its endocardial expression is required to promote normal cellularity in the developing endocardial cushion, and SMAD4 is required to promote proliferation during the activation process of the pre-endothelial-to-mesenchymal transformation endocardial cell |
|
plays a crucial role in regulating the interplay between TGFB/BMP and WNT signaling to ensure the proper cranial neural crest cell fate decision during organogenesis |
|
crucial role in TGFB/bone morphogenetic protein (BMP) signal transduction |
|
potentially required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors |
|
cooperative regulation of VEGFA signaling by FHL1 and SMAD4 was evidenced, which may provide a novel regulation mechanism underlying cancer development and progression |
|
is essential for initiating the SMC differentiation program during ureter development |
|
SMAD4 and STRA8 are essential factors that regulate the female fate of germ cells |
|
BSG -induced cell proliferation is associated with SMAD4 signal inhibition |
|
SMAD4 is tyrosine-phosphorylated by an oncogenic tyrosine kinase during tumorigenesis, suggesting a mechanism by which SMAD4 is inactivated in cancers |
|
functional role of the TRIM47-SMAD4-CCL15 axis in colorectal cancer (CRC) progression |
|
SMAD4 activates WNT signaling pathway to inhibit granulosa cell apoptosis |
|
contributes to chondrocyte and osteocyte development |
|
critical regulator of cardiac neural crest cell fate and vascular smooth muscle development |