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FLASH GENE
Symbol SLX1B contributors: mct - updated : 19-05-2014
HGNC name GIY-YIG domain containing 2
HGNC id 28748
Location 16p11.2      Physical location : -
Synonym symbol(s) MGC5178, FLJ23439, MGC2532, GIYD2
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping
text overlapping with exons of the phenol-preferring sulfotransferase SULT1A4 gene
STRUCTURE 3.72 kb     5 Exon(s)
text structure a segmental duplication of the p arm of chromosome 16 created two identical copies of the GIY-YIG domain containing gene
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1170 30 275 - 2009 19596236
  • isoform 1
  • 5 - 828 17 161 - 2009 19596236
  • lacking an alternate in-frame segment in the coding region
  • isoform 2
  • predicted orf
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLX1A, and SLX1B like MUS81-EME1, is required for repair of DNA interstrand crosslinks, but this role appears to be independent of Holliday junctions (HJs) cleavage
  • GEN1 and the BTBD12-associated nucleases MUS81 and SLX1A and SLX1B are essential for the resolution of replication-induced Holliday junctions '
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS