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FLASH GENE
Symbol SLX1A contributors: mct/npt - updated : 19-05-2014
HGNC name SLX1 structure-specific endonuclease subunit homolog A
HGNC id 20922
Location 16p11.2      Physical location : -
Synonym name
  • structure-specific endonuclease subunit SLX1
  • GIY-YIG domain containing 1
  • Synonym symbol(s) SLX1, GIYD1
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping
    text overlap with exons of the phenol-preferring sulfotransferase (SULT1A3) gene
    STRUCTURE 3.72 kb     6 Exon(s)
    text structure a segmental duplication of the p arm of chromosome 16 created two identical copies of the GIY-YIG domain containing gene
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1170 - 275 - 2009 19596235
    5 - 828 - 161 - 2009 19596235
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Reproductivefemale systemuteruscervix  
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a GIY-YIG-type nuclease domain
  • HOMOLOGY
    Homologene
    FAMILY
  • SLX1 family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • regulator of structure-specific nucleases and with BTBD12 are important regulators of genome stability in human cells (Munoz 2009)
  • in addition to 5prime flap endonuclease activity, SLX1A-BTBD12 has a robust Holliday junction resolvase activity (Fekairi 2009)
  • with BTBD12 have important functions in the maintenance of genome integrity and in the tolerance to DNA damage inflicted by an alkylating agent (Fekairi 2009)
  • resolvase that processes Holliday junctions during homologous recombination-mediated DNA double strand break repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLX1A-BTBD12 module promotes symmetrical cleavage of static and migrating Holliday junctions (HJs), identifying GIYD1-BTBD12 as a HJ resolvase (Svendsen 2009)
  • coordinated actions of SLX1A-BTBD12 and MUS81-EME1 for Holliday junction resolution
  • SLX1A, and SLX1B like MUS81-EME1, is required for repair of DNA interstrand crosslinks, but this role appears to be independent of Holliday junctions (HJs) cleavage
  • GEN1 and the BTBD12-associated nucleases MUS81 and SLX1A and SLX1B are essential for the resolution of replication-induced Holliday junctions '
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS