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FLASH GENE
Symbol SLU7 contributors: mct - updated : 16-09-2019
HGNC name SLU7 homolog, splicing facto
HGNC id 16939
Location 5q33.3      Physical location : 159.828.648 - 159.846.168
Genatlas name step II splicing factor SLU7
Synonym name
  • zinc knuckle motif containing
  • Synonym symbol(s) hSlu7, MGC9280, 9G8
    DNA
    TYPE functioning gene
    STRUCTURE 17.44 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • several functional Ets binding sites and GC-boxes in the human SLU7 promoter region
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC348938 5q33.3 hypothetical protein LOC348938 ADAM19 5q32-q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) SOX30 5q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) LOC389341 5 similar to RIKEN cDNA 4921536K21 FLJ20546 5q33.3 hypothetical protein FLJ20546 LSM11 5q33.3 U7 snRNA-associated Sm-like protein ENTH 5q23.1-q33.3 U7 snRNA-associated Sm-like protein LOC391843 5 similar to 60S acidic ribosomal protein P2 LOC345471 5q33.3 similar to Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) LOC285721 5q33.3 hypothetical LOC285721 EBF 5q34 early B-cell factor FLJ31951 5q33.3 hypothetical protein FLJ31951 MGC10067 5q33.3 hypothetical protein MGC10067 IL12B 5q31.1-q33.1 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) ADRA1B 5q33.1 adrenergic, alpha-1B-, receptor TTC1 5q32-q33.2 tetratricopeptide repeat domain 1 KIAA1935 5q34 KIAA1935 protein FABP6 5q23-q35 fatty acid binding protein 6, ileal (gastrotropin) FLJ14166 5q34 hypothetical protein FLJ14166 C1QTNF2 5q33.3 C1q and tumor necrosis factor related protein 2 LOC63920 5q34 transposon-derived Buster3 transposase-like SLU7 5q34 step II splicing factor SLU7 PTTG1 5q35.1 pituitary tumor-transforming 1 FLJ21477 5q34 hypothetical protein FLJ21477 GABRB2 5q33.1-q34 gamma-aminobutyric acid (GABA) A receptor, beta 2 GABRA6 5q33.1-q33.2 gamma-aminobutyric acid (GABA) A receptor, alpha 6 GABRA1 5q33.2 gamma-aminobutyric acid (GABA) A receptor, alpha 1 GABRG2 5q31.3-q33.2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 MRP63P6 5q34 mitochondrial ribosomal protein 63 pseudogene 6 CCNG1 5q32-q34 cyclin G1 LOC134492 5q34 similar to RIKEN cDNA 2700047N05 HMMR 5q33.3 hyaluronan-mediated motility receptor (RHAMM)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3478 - 601 - 2014 24865429
    16 - 3480 - 586 - 2014 24865429
    17 - 3608 - 586 - 2014 24865429
    17 - 3612 - 586 - 2014 24865429
    17 - 3570 - 596 - 2014 24865429
    16 - 3905 - 586 - 2014 24865429
    16 - 3907 - 596 - 2014 24865429
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Lymphoid/Immunelymph node   predominantly
     spleen   moderately
    Reproductivefemale systemuterus  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal segment of SLU7 (AAs 62196) resembles a tripod and mainly interacts with PRPF8
  • a zinc knuckle motif
  • C-terminal segment of SLU7, comprising four alpha helices interspersed by extended loops, has two subdomains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • being essential during the second catalytic step in the pre-mRNA splicing process
  • highly conserved splicing factor SLU7 is involved in 3' splice site selection and also regulates alternative splicing
  • pre-mRNA splicing regulator that is inhibited in hepatocarcinoma, and is a pivotal gene for hepatocellular homeostasis
  • is central regulator of hepatocyte identity and quiescence
  • splicing regulator SLU7 as a key mediator of genome stability
  • conserved and fundamental role of SLU7 in the preservation of genome integrity
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component associated with the spliceosome
    INTERACTION
    DNA
    RNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • during step 1 of splicing, PRPF8 interactions with SF3b proteins are replaced by SLU7, positioning this second step factor close to the active site, and that the DEAH-box helicases DHX16 and DHX38 cooperate through ordered interactions with GPKOW (PMIDl:
  • SLU7 and PRPF18, which promote exon ligation, bind together to the PRPF8 RNase H-like domain
  • SLU7 adopts an extended conformation, binds PRPF8 and CWC22, and is poised for selection of the 3'-splice site
  • PRPF8 plays a key role in positioning the 5'splice sites (SSs) and 3'SS, facilitated by SLU7 through interactions with PRPF8 and substrate RNA to advance exon ligation
  • cell & other
    REGULATION
    Other complex transcription regulation mechanism that controls the spatial and temporal expression of SLU7, presumably allowing regulation of tissue-specific alternative splicing events
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the cirrhotic liver could be involved in the process of hepatocarcinogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS