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FLASH GENE
Symbol SLPI contributors: mct/npt/pgu - updated : 22-02-2010
HGNC name secretory leukocyte protease inhibitor (antileukoproteinase)
HGNC id 11092
Location 20q13.12      Physical location : 43.880.878 - 43.883.206
Synonym name
  • human seminal plasma inhibitor 1
  • mucus proteinase inhibitor
  • WAP four-disulfide core domain 4
  • Synonym symbol(s) HUSI-I, BLPI, ALK1, ALP, WAP4, WFDC4
    DNA
    TYPE functioning gene
    STRUCTURE 2.33 kb     4 Exon(s)    1 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box) (TATA box)
    HSs hypertensive site
    Binding site
    text structure
  • two DNase I hypersensitory sites in HS-24 cells
  • two contignous transcription start sites
  • MAPPING cloned Y linked N status provisional
    Physical map
    ADA 20q12 adenosine deaminase MGC5566 20q13.12 hypothetical protein MGC5566 WISP2 20q12-q13.1 WNT1 inducible signaling pathway protein 2 KCNK15 20q12-q13 potassium channel, subfamily K, member 15 RIMS4 20 regulating synaptic membrane exocytosis 4 LOC391252 20 similar to piggyBac transposable element derived 4 YWHAB 20q13.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide LOC200226 20q13.12 similar to Polyadenylate-binding protein 2 (Poly(A)-binding protein 2) (PABP 2) TOMM34 20q12-q13.11 translocase of outer mitochondrial membrane 34 STK4 20q11.2-q13.2 serine/threonine kinase 4 KCNS1 20q12 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 WFDC5 20q13.11 WAP four-disulfide core domain 5 WFDC12 20q12-q13.1 WAP four-disulfide core domain 12 PI3 20q12-q13 protease inhibitor 3, skin-derived (SKALP) SEMG1 20q13.1 semenogelin I SEMG2 20q13.1 semenogelin II LOC149709 20q13.12 similar to RIKEN cDNA 1700049M11 SLPI 20q12-q13.2 secretory leukocyte protease inhibitor (antileukoproteinase) MATN4 20q13.1-q13.2 matrilin 4 RBPSUHL 20q12-q13.1 recombining binding protein suppressor of hairless (Drosophila)-like SDC4 20q13.1 syndecan 4 (amphiglycan, ryudocan) C20orf35 20q13.12 chromosome 20 open reading frame 35 C20orf10 20q12-13.12 chromosome 20 open reading frame 10 PIGT 20q12-q13.1 phosphatidyl inositol glycan class T LOC149710 20q13.12 hypothetical LOC149710 WFDC2 20q12-q13.2 WAP four-disulfide core domain 2 WFDC6 20q13.12 WAP four-disulfide core domain 6 SPINLW1 20q12-q13.2 serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin) WFDC8 20q13.12 WAP four-disulfide core domain 8 WFDC9 20q12-q13.1 WAP four-disulfide core domain 9 WFDC10A 20q13.12 WAP four-disulfide core domain 10A RPS2L1 20q13.11 ribosomal protein S2-like 1 WFDC11 20q12-q13.1 WAP four-disulfide core domain 11 WFDC10B 20 WAP four-disulfide core domain 10B WFDC13 20q13.12 WAP four-disulfide core domain 13 LOC391253 20 similar to dJ601O1.1 (novel protein with Kunitz/Bovine pancreatic trypsin inhibitor domain) HNRPA1P3 20q13.12 heterogeneous nuclear ribonucleoprotein A1 pseudogene 3 WFDC3 20q13.12 WAP four-disulfide core domain 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 598 - 132 - 2009 PMID: 193333
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly Homo sapiens
     salivary gland   highly Homo sapiens
    Respiratoryrespiratory tracttrachea  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothmyoepithelium highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion secreted by epithelial cells in all the mucosal fluids such as saliva, cervical mucus, as well in the seminal liquid, bronchial secretions
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two acid stable polypeptide functional domains (thypsin inhibitory site
  • elastase inhibitory site)
  • two WAP type domains, WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
  • secondary structure eight disulfide bonds
    HOMOLOGY
    interspecies homolog to murine Slpi
    homolog to C.elegans c45g7.3
    Homologene
    FAMILY
  • WAP-type "four-disulfide core" domain proteins family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    text
  • secreted by epithelial cells in all the mucosal fluids such as saliva, cervical mucus, as well in the seminal liquid
  • predominantly localized in the nuclei of myocytes and colocalized with CD68(+) macrophages
  • basic FUNCTION
  • secretory leukoprotease inhibitor
  • involved in antineutrophil elastase protection at inflammatory sites
  • protecting epithelial tissues from serine proteases
  • prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity
  • can inhibit interferon-gamma-induced cathepsin S production by macrophages
  • cationic non-glycosylated antiprotease synthesized and secreted by cells at the site of inflammation
  • able to disrupt the association between PLSCR1 and CD4, suggesting that SLPI inhibits HIV-1 infection by modulating the interaction of the CD4 receptor with PLSCRs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for the phospholipid scramblase 1 (PLSCR1) and PLSCR4, membrane proteins that are involved in the regulation of the movements of phospholipids between the inner and outer leaflets of the plasma membrane
  • MMP12 is a PGRN proteolytic enzyme, and SLPI an inhibitor of MMP12-induced PGRN proteolysis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly decreased in prostate cancers compared with that in benign prostate epithelial cells
    constitutional     --over  
    expressed in myometrium and increased after the onset of labor
    Susceptibility
    Variant & Polymorphism
    Candidate gene for lipodystrophy and diabetes
    Marker
    Therapy target
  • may constitute new targets for antiviral intervention
  • therapeutically important as a potential inhibitor of protease expression in chronic obstructive pulmonary disease
  • ANIMAL & CELL MODELS