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FLASH GENE
Symbol SLN contributors: mct - updated : 23-10-2017
HGNC name sarcolipin
HGNC id 11089
Location 11q22.3      Physical location : 107.578.108 - 107.582.787
Synonym symbol(s) SARL, MGC12301, MGC125854, MGC125855
DNA
TYPE functioning gene
STRUCTURE 4.69 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 738 3.63 31 - 1997 9367679
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
 heartatrium  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac   Homo sapiens
Muscularstriatumskeletal highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • low molecular weight proteolipid
  • a conserved threonine 5 at the N-terminus of SLN critically regulating SLN function and mediates beta-adrenergic responses , and deletion of SLN N-terminal residues (2)ERSTQ leads to loss of the uncoupling function even though the truncated peptide can target and constitutively bind ATP2A1
  • has a conserved C-terminal luminal tail composed of five amino acids ((27)RSYQY), which may contribute to a distinct ATP2A1 regulatory mechanism; C-terminal tail of SLN is a distinct, essential domain in the regulation of ATP2A1 and the functional properties of the SLN tail can be transferred to PLN
  • HOMOLOGY
    intraspecies homolog to phospholamban
    Homologene
    FAMILY
  • sarcolipin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • sarco(endo)plasmic reticulum (SR) membrane protein
  • transmembrane protein expressed in the sarco/endoplasmic reticulum of skeletal and atrial muscles
  • basic FUNCTION
  • regulator of the sarco(endo)plasmic reticulum Ca(2+)-ATPase of fast-twitch skeletal muscle (SERCA1a)
  • inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)
  • its downregulation could play an important role in abnormal intracellular Ca2+ cycling in atrial pathology
  • is likely an important mediator of muscle thermogenesis and whole-body energy metabolism
  • effect of PLN and SLN, which becomes synergic when they are both present in the SR membrane, is expected to favor a rapid equilibration of ions on both sides of the membrane
  • SLN provides likely a novel mechanism of adaptive thermogenesis within skeletal muscle and protects against diet-induced obesity
  • important role for SLN in muscle metabolism and energy expenditure
  • SLN and its close analog phospholamban (PLN) are membrane proteins that regulate SERCA by inhibiting Ca(2+) transport in skeletal and cardiac muscl
  • small proteolipid and a regulator of sarco(endo)plasmic reticulum Ca(2+)-ATPase
  • transmembrane protein that can form a self-assembled pentamer
  • SLN, not PLN, is required for muscle-based thermogenesis
  • regulator of ATP2A1 activity in muscle, playing an important role in regulating muscle thermogenesis and metabolism
  • potential role for SLN during increased metabolic demand
  • plays an important role in adaptive muscle remodeling potentially through calcineurin stimulation, which could have important implications for other muscle diseases and conditions
  • plays crucial roles in heat production through modifying the function of sarco/endoplasmic reticulum Ca2+ ATPase, thereby being involved in thermogenesis and systemic metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with the fast-twitch skeletal muscle sarcoplasmic reticulum Ca++ ATPase (ATP2A1)
  • inhibitor of cardiac sarcoplasmic reticulum Ca2+-ATPase (SERCA)
  • SLN and STIM1 act in opposing fashions to govern store operated Ca(2+) entry (SOCE) during myogenesis
  • SLN binding to ATP2A1 uncouples Ca(2+) transport from ATP hydrolysis
  • SLN and PLN inhibit ATP2A1 by using a similar mechanism
  • ANK1 interacts likely with SLN both directly and in complex with ATP2A1 and reduces SLN inhibitory effect on ATP2A1 activity
  • inhibitor of the sarco/endoplasmic reticulum (SR) Ca2+ ATPase (SERCA)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in tetralogy of Fallot
    constitutional     --low  
    in chronic atrial fibrillation (AF)
    constitutional     --low  
    in atria from heart failure patients
    constitutional     --over  
    in the muscle of Duchenne muscular dystrophy (DMD) patients
    constitutional     --low  
    results in cardiac hypertrophy and decreased cardiac contractility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neuromuscularmyopathydegenerative
    SLN reduction is a promising therapeutic approach for DMD
    ANIMAL & CELL MODELS
  • ablation of sarcolipin (Sln), a regulatory protein and uncoupler of sarco(endo)plasmic reticulum Ca2+-ATPases, leads to excessive diet-induced obesity and glucose intolerance in mice