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FLASH GENE
Symbol SLITRK6 contributors: mct - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 6
HGNC id 23503
Corresponding disease
DFNMYP deafness and myopia
Location 13q31.1      Physical location : 86.366.921 - 86.373.483
Synonym name slit and trk like gene 6
Synonym symbol(s) FLJ22774, DKFZp564O1278, DFNMYP
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 6.56 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC390413 13 similar to 60S ribosomal protein L7 DHX9P 13q21 DEAH (Asp-Glu-Ala-His) box polypeptide 9 pseudogene CLN5 13q22 ceroid-lipofuscinosis, neuronal 5 FBXL3A 13q22 F-box and leucine-rich repeat protein 3A PAM 5q15 peptidylglycine alpha-amidating monooxygenase SCEL 13q22 sciellin LOC390414 13 similar to chromosome 15 open reading frame 2 FLJ30046 13q22.1 hypothetical protein FLJ30046 EDNRB 13q22 endothelin receptor type B POU4F1 13q21.1-q22 POU domain, class 4, transcription factor 1 C13orf7 13q22.2 chromosome 13 open reading frame 7 LOC341732 13q22.2 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) LOC390415 13 similar to T-complex protein 1, epsilon subunit (TCP-1-epsilon) (CCT-epsilon) C13orf10 13q22.1 chromosome 13 open reading frame 10 NDFIP2 13q22.1 Nedd4 family interacting protein 2 SPRY2 13q31-q32 sprouty homolog 2 (Drosophila) LOC150928 13q22.3 hypothetical LOC150928 SLITRK1 13q31.1 SLIT and NTRK-like family, member 1 VENTX2P2 13q31.1 VENT-like homeobox 2 pseudogene 2 LOC387939 13 LOC387939 SLITRK6 13q31.1 SLIT and NTRK-like family, member 6 LOC390417 13 similar to probable RNA helicase (EC 3.6.1.-) RCK - human SLITRK5 13q31.1 slit and trk like gene 5 LOC387940 13 LOC387940 LOC160824 13q31.2 similar to Transcription factor Sp3 (SPR-2) LOC121727 13q31.2-q31.3 similar to Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor-3) (PAF-3) LOC390418 13 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC390419 13 similar to peptidyl-Pro cis trans isomerase GPC5 13q32 glypican 5 GPC6 13q32 glypican 6 DCT 13q32 dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4199 - 841 - 2003 14557068
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Hearing/Equilibriumearinner  highly Homo sapiens
Nervousbrainforebraincerebral cortex highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensorystato-auditory highly Homo sapiens
cell lineage
cell lines medulloblastomas and primitive neuroectodermal tumors
fluid/secretion
at STAGE
physiological period fetal
Text lung, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domains containing two clusters of LRRs (16 LRR (leucine-rich) repeats)
  • HOMOLOGY
    interspecies homolog to rattus LOC290467
    ortholog to murine Slitrk6
    Homologene
    FAMILY SLITRK family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • suppresses neurite outgrowth
  • promotes innervation and survival of inner ear sensory neurons by regulating the expression of trophic and/or tropic factors including neurotrophins from sensory epithelia
  • has a critical role in the development of the inner ear neural circuit
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNMYP
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    brain tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Slitrk6-deficient mice showed pronounced reduction in the cochlear innervation