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FLASH GENE
Symbol SLITRK4 contributors: mct - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 4
HGNC id 23502
Location Xq27.3      Physical location : 142.710.595 - 142.723.926
Synonym name slit and trk like gene 4
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 13.32 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 8742 - 837 - 2003 14557068
2 - 8695 - 837 - 2003 14557068
2 - 8545 - 837 - 2003 14557068
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex   Homo sapiens
cell lineage
cell lines astrocytomas, gliobastomas and primitive neuroectodermal tumors
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domains containing two clusters of LRRs (18 LRR (leucine-rich) repeats)
  • HOMOLOGY
    interspecies homolog to rattus LOC302473
    homolog to murine Slitrk4
    Homologene
    FAMILY SLITRK family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • suppressing neurite outgrowth
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • SLITRK1, SLITRK2, SLITRK4, and SLITRK5 specifically acted at excitatory synapses in various functional assays
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS