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FLASH GENE
Symbol SLITRK2 contributors: mct - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 2
HGNC id 13449
Location Xq27.3      Physical location : 144.899.346 - 144.907.358
Synonym name slit-like 1 (Drosophila)
Synonym symbol(s) CXorf2, SLITL1, KIAA1854
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 8.01 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4417 - 845 - 2003 14557068
5 - 3944 - 845 - 2003 14557068
5 - 3934 - 845 - 2003 14557068
5 - 3922 - 845 - 2003 14557068
3 - 4166 - 845 - 2003 14557068
3 - 4154 - 845 - 2003 14557068
3 - 4144 - 845 - 2003 14557068
2 - 4007 - 845 - 2003 14557068
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiens
Respiratoryrespiratory tractlarynx   
Skin/Tegumentskin    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domains containing two clusters of LRRs (14 LRR (leucine-rich) repeats)
  • HOMOLOGY
    Homologene
    FAMILY SLITRK family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • suppressing neurite outgrowth
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • SLITRK1, SLITRK2, SLITRK4, and SLITRK5 specifically acted at excitatory synapses in various functional assays
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia and bipolar disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS