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FLASH GENE
Symbol SLIT3 contributors: mct/npt - updated : 28-05-2010
HGNC name slit homolog 3 (Drosophila)
HGNC id 11087
Location 5q35.1      Physical location : 168.093.071 - 168.728.133
Synonym name
  • SLIT (Drosophila) homolog 2
  • multiple epidermal growth factor-like domain 5
  • Synonym symbol(s) MEGF5, SLIL2, SLIT1, MEGF5, FLJ10764, KIAA0814
    DNA
    TYPE functioning gene
    STRUCTURE 635.06 kb     36 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391846 5 similar to 60S ribosomal protein L7 LOC134541 5q35.1 similar to Ten-m2 ODZ2 5q35.1 odd Oz/ten-m homolog 2 KIBRA 5q35.1 KIBRA protein RARS 5pter-q11 arginyl-tRNA synthetase LOC345630 5q35.1 similar to fibrillarin PANK3 5q35 pantothenate kinase 3 LOC389342 5 similar to 60S ribosomal protein L10 (QM protein homolog) SLIT3 5q35 slit homolog 3 (Drosophila) FLJ20364 5q35.1 hypothetical protein FLJ20364 DOCK2 5q35.1 dedicator of cyto-kinesis 2 FOXI1 5q34 forkhead box I1 LOC345430 5q35.1 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC133874 5q35.1 hypothetical gene LOC133874 LCP2 5q34 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) KCNMB1 5q34 potassium large conductance calcium-activated channel, subfamily M, beta member 1 KCNIP1 5q35.2 Kv channel interacting protein 1 LOC389343 5 LOC389343 GABRP 5q33-q34 gamma-aminobutyric acid (GABA) A receptor, pi RANBP17 5q31 RAN binding protein 17 USP12P1 5q33-q34 ubiquitin specific protease 12 pseudogene 1 TLX3 5q35.1 T-cell leukemia, homeobox 3 LOC391847 5 similar to hypothetical protein LOC391848 5 similar to 60S ribosomal protein L10 (QM protein homolog) NPM1 5q35 nucleophosmin (nucleolar phosphoprotein B23, numatrin) FGF18 5q34 fibroblast growth factor 18
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    36 - 5395 167.4 1523 - Itoh, Little (2001)
    major transcript
    - - 9500 - 1523 thyroid Itoh, Little (2001)
    minor transcript
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   predominantly Homo sapiens
     thyroid    
    Nervousbrainhindbraincerebellum  
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text co-expressed in embryonic stem (ES) cells with embryoid body formation (Katoh 2005)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal mitochondrial localization signal that can direct a reporter green fluorescent protein to the mitochondria
  • secretory protein with four leucine rich repeats (LRR)
  • two calcium binding type
  • nine EGF domains
  • Laminin G (LamG) domain, and SLITCCR domain (Katoh 2005)
  • seven EGF-like motifs
  • HOMOLOGY
    interspecies homolog to SLIT Drosophila 3
    homolog to murine Slit3
    Homologene
    FAMILY
  • laminin G family
  • CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • predominantly localized within the mitochondria (Little 2001)
  • maximal in the late-luteal phase and significantly reduced after luteal rescue (Dickinson 2008)
  • basic FUNCTION
  • chemorepellent, involved in histogenesis of central nervous system and endocrine systems
  • has potentially unique functions not shared by other Slit proteins (Little 2001)
  • involved in the formation of the diaphragm and kidney during embryogenesis (Tanno 2007)
  • functions as an intracellular signaling molecule for cell motility as part of the LPS-induced signaling cascade (Tanno 2007)
  • axon-guidance-pathway molecules are involved in connectivity and repair throughout life (beyond guiding brain wiring during fetal development) (Lin 2009)
  • dispensable for neural development but required for non-neuron-related developmental processes, such as the genesis of the diaphragm and kidney (Zhang 2009)
  • repulsive axon guidance molecule which is a novel and potent angiogenic factor and functions to promote angiogenesis in coordinating organogenesis during embryonic development (Zhang 2009)
  • role during the angiogenic process that relies on the directional migration not only of endothelial cells but also of pericytes
  • SLIT2 may act in an autocrine manner on beta cells, whereas SLIT1 and SLIT3 may play both autocrine and paracrine roles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text
  • neurogenesis
  • maintenance of dorsal position by preventing axonal growth into the ventral region
  • prevention of axonal extension toward and across the midline
  • channneling of axons toward particular region
  • PATHWAY
    metabolism
    signaling
    SLIT signaling depletes ER Ca2+ and protects beta cells from ER stress
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand to GPC1(glypican 1)
  • ligand for ROBO proteins increasing SrGAP1-ROBO1 interaction
  • inactivating CDC42
  • cell & other
    REGULATION
    induced by lipopolysaccharide (LPS)-stimulation in macrophages (Tanno 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in human cancers and may regulate apoptosis and metastasis (Dickinson 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS