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FLASH GENE

Symbol

SLFN5

contributors: mct/npt - updated : 16-01-2010

HGNC name	schlafen family member 5
HGNC id	28286

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q12      Physical location : 33.570.085 - 33.594.754
Synonym symbol(s)	MGC19764, MGC150612, MGC150611

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	24.69 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144975 6 - 4660 NP_659412 100 891 - Schwartz (1998)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

common N-terminal (AAA) domain that is involved in GTP/ATP binding (Katsoulidis 2009)

HOMOLOGY

Homologene

FAMILY

schlafen family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	control cell cycle progression and growth arrest (Katsoulidis 2009)
	promote growth inhibitory responses and modulate cell cycle progression by inhibiting cyclin D1 (Katsoulidis 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS