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FLASH GENE
Symbol SLCO6A1 contributors: mct - updated : 03-10-2019
HGNC name solute carrier organic anion transporter family, member 6A1
HGNC id 23613
Location 5q21.1      Physical location : 101.707.653 - 101.834.720
Synonym name
  • gonad-specific transporter
  • testis-specific organic anion transporter
  • cancer/testis antigen 48
  • organic anion-transporting polypeptide I
  • solute carrier family 21 member 19
  • testicular tissue protein Li 174
  • Synonym symbol(s) OATPY, OATP6A1, MGC26949, GST, CT48, OATP-I, SLC21A19
    DNA
    TYPE functioning gene
    STRUCTURE 130.44 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    CAST 5q15-q21 calpastatin ARTS-1 5q15 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator LRAP 16 leukocyte-derived arginine aminopeptidase FLJ39485 5q15 hypothetical protein FLJ39485 LNPEP 5q21 leucyl/cystinyl aminopeptidase FLJ25534 5q15 hypothetical protein FLJ25534 RIOK2 5q14 RIO kinase 2 (yeast) LOC391812 5 similar to Dermatomyositis associated with cancer putative autoantigen-1 (DACA-1) LOC391813 5 similar to Zinc finger DHHC domain containing protein 3 (Zinc finger protein 373) (DHHC1 protein) LOC389312 5 similar to Proteasome activator complex subunit 2 (Proteasome activator 28-beta subunit) (PA28beta) (PA28b) (Activator of multicatalytic protease subunit 2) (11S regulator complex beta subunit) (REG-beta) LOC391814 5 similar to cytoplasmic beta-actin MRPS35P2 5q15 mitochondrial ribosomal protein S35 pseudogene 2 LOC285703 5q21.1 similar to C-terminal binding protein 2 isoform 2; ribeye LOC391815 5 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) FLJ90406 CHD1 5q15-q21 chromodomain helicase DNA binding protein 1 LOC389313 5 LOC389313 LOC256055 5q21.1 similar to Beta-glucuronidase precursor (Beta-G1) LOC285706 5q21.1 cytokine receptor-like factor 3 pseudogene LOC389314 5 similar to NADH dehydrogenase subunit 5 LOC389315 5 LOC389315 UNQ1912 5q21.1 HGS_RE408 SIAT8D 5p21 sialyltransferase 8D (alpha-2, 8-polysialyltransferase) SLCO4C1 5q21.2 solute carrier organic anion transporter family, member 4C1 SLCO6A1 5q21.2 solute carrier organic anion transporter family, member 6A1 PAM 5q15 peptidylglycine alpha-amidating monooxygenase LOC134505 5q21.2 similar to eukaryotic translation initiation factor 3 subunit k; muscle specific gene FLJ20125 5q21.2 hypothetical protein FLJ20125 KIAA0433 5q21-q23 hypothetical protein FLJ20125 LOC90355 5q21.2 hypothetical gene supported by AF038182; BC009203 LOC345761 5q21.3 similar to 2610034M16Rik protein NUDT12 5q15 nudix (nucleoside diphosphate linked moiety X)-type motif 12 RAB9P1 5q14.3-q15 RAB9, member RAS oncogene family, pseudogene 1 LOC345571 5q21.3 similar to rap2 interacting protein x LOC391817 5 similar to protease (prosome, macropain) 26S subunit, ATPase 1 EFNA5 5q21 ephrin-A5 LOC391818 5 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) LOC345576 5q21.3 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) FBXO13 5q21.3 F-box only protein 13
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2544 - 719 - 2003 12677006
    9 - 1871 - 466 - 2003 12677006
    13 - 2496 - 657 - 2003 12677006
    14 - 2630 - 719 - 2003 12677006
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve predicted transmembrane domains, which is a common structure of organic anion transporters
  • HOMOLOGY
    interspecies ortholog to murine Slco6b1
    ortholog to rattus Slco6b1
    Homologene
    FAMILY
  • organo anion transporter (TC 2.A.60) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be involved in the regulation of sex steroid transportation and spermatogenesis in the gonad
  • organic anion transport transmembrane protein attributed as being responsible for transporting dehydroepiandrosterone sulfate and thyroid hormones involved in the regulation of spermatogenesis in the gonad
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to major depressive disorder (MDD)
  • Variant & Polymorphism other
  • rs7734060 could be a risk locus for MDD
  • Candidate gene
    Marker
  • might be novel biomarker for tumor progression and the development of metastasis in small cell lung cancer (SCLC) patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    could be a target for antibody-based immunotherapy for a variety of tumors, including medulloblastoma
    ANIMAL & CELL MODELS