Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLCO5A1 contributors: mct - updated : 03-10-2019
HGNC name solute carrier organic anion transporter family, member 5A1
HGNC id 19046
Corresponding disease
DEL8q13 chromosome 8q13 microdeletion
Location 8q13.3      Physical location : 70.584.569 - 70.747.299
Synonym name
  • organic anion transporter polypeptide-related protein 4
  • solute carrier family 21 (organic anion transporter), member 15
  • solute carrier family 21 member 15
  • Synonym symbol(s) OATP-J, OATPRP4, SLC21A15, OATP5A1, FLJ39560
    DNA
    TYPE functioning gene
    STRUCTURE 162.63 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3806 91.9 848 - 2003 12507753
    9 - 3430 85.8 793 - 2003 12507753
    8 - 3751 73.8 687 - 2003 12507753
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Nervousbrain   highly
    Reproductivefemale systemuterus   
     female systembreastmammary gland   Homo sapiens
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly expressed in fetal brain and heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12 transmembrane domains
  • HOMOLOGY
    Homologene
    FAMILY
  • solute carrier organic anion transporter superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • SLCO5A1 and SLCO3A1 localized to the plasma membrane of epithelial cells of the lactiferous ducts in normal breast tissue
  • basic FUNCTION
  • mediating the Na(+)-independent transport of organic anions
  • might be a non-classical OATP family member which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL8q13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might be novel biomarker for tumor progression and the development of metastasis in small cell lung cancer (SCLC) patients
  • Therapy target
    ANIMAL & CELL MODELS