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FLASH GENE
Symbol SLCO2B1 contributors: shn - updated : 05-09-2010
HGNC name solute carrier organic anion transporter family, member 2B1
HGNC id 10962
Location 11q13.4      Physical location : 74.862.039 - 74.917.444
Synonym name
  • solute carrier family 21 (organic anion transporter), member 9
  • organic anion transporter B
  • organic anion transporter polypeptide-related protein 2
  • solute carrier family 21 member 9
  • solute carrier organic anion transporter family member 2B1
  • Synonym symbol(s) DKFZp686E0517, KIAA0880, OATP-B, OATP2B1, OATPB, SLC21A9, OATP-RP2, OATPRP2
    DNA
    TYPE functioning gene
    STRUCTURE 55.41 kb     14 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D11S4207 - D11S4119 - SLCO2B1 - D11S4128 - D11S4081 - qter
    Physical map
    PLEKHB1 11q13.5-q14.1 pleckstrin homology domain containing, family B (evectins) member 1 RAB6A 2q14-q21 RAB6A, member RAS oncogene family LOC268276 11q13 musashi 1 pseudogene MRPL48 11q13.2 mitochondrial ribosomal protein L48 E2IG2 11q13.3 E2IG2 protein FLJ11848 11q13.3 hypothetical protein FLJ11848 TSARG6 11q13.3 testis spermatogenesis apoptosis-related protein 6 UCP2 11q13 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 11q13 uncoupling protein 3 (mitochondrial, proton carrier) DKFZP586P0123 11q13.3 DKFZP586P0123 protein PME-1 11q13.3 protein phosphatase methylesterase-1 LOC283208 FLJ32029 KCNE3 11q13-q14 potassium voltage-gated channel, Isk-related family, member 3 HCP27 11q13.3 cytochrome c, somatic pseudogene LOC387787 11 similar to RIKEN cDNA 2610209A20 POLD3 11q14 similar to RIKEN cDNA 2610209A20 BNF1 FLJ22596 11q13.3 hypothetical protein FLJ22596 LOC387788 11 similar to ribosomal protein S12 KIAA1991 11q13.3 hypothetical protein KIAA1991 KIAA0102 11q13.3 hypothetical protein KIAA1991 LOC387789 11 LOC387789 NEU3 11q13.5 sialidase 3 (membrane sialidase) LOC390224 11 similar to olfactory receptor MOR101-2 LOC341152 11q13.3 similar to olfactory receptor MOR101-1 LOC390225 11 similar to olfactory receptor MOR101-2 SLCO2B1 11q13 solute carrier organic anion transporter family, member 2B1 ARRB1 11q13 arrestin, beta 1 RPS3 11q13.3-q13.5 ribosomal protein S3 FLJ33790 11q13.3 hypothetical protein FLJ33790 PP1665 11q13.3 hypothetical protein PP1665 SERPINH1 11q13.5 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) MAP6 6p12-p11 microtubule-associated protein 6 MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase DGAT2 11q13.3 diacylglycerol O-acyltransferase homolog 2 (mouse) UVRAG 11q13 UV radiation resistance associated gene WNT11 11q13.5 wingless-type MMTV integration site family, member 11 PRKRIR 11q13.5 protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) LOC387790 11 LOC387790 C11orf30 11q13.5 chromosome 11 open reading frame 30 GARP 11q13.5-q14 glycoprotein A repetitions predominant LOC390226 11 similar to Olfactory guanylyl cyclase GC-D precursor (Guanylate cyclase, olfactory)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 4354 85 709 choroid/RPE-complex and ciliary body St-Pierre et al, 2002; Kraft et al, 2010
    11 splicing 3922 - 565 - -
    14 splicing 4056 - 687 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    Cardiovascularheart   lowly
    Digestiveliver   highly
    Endocrinepancreas   lowly
    Nervousbrain   lowly
    Reproductivefemale systemovary  lowly
     male systemtestis  lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    Visualeyeretina  lowly
     eyeanterior segmentiris lowly
     eyeanterior segmentcornea lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE) highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight transmembrane domains
  • N-glycosylation sites
  • HOMOLOGY
    interspecies ortholog to Slco2b1, Rattus norvegicus
    ortholog to slco2b1, Danio rerio
    ortholog to SLCO2B1, Pan troglodytes
    ortholog to Slco2b1, Mus musculus
    Homologene
    FAMILY organic anion transporting polypeptide (OATP) family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transport of 3(H) estrone-3-sulfate
  • a physiological role in the placental uptake of fetal-derived sulfated steroids (St-Pierre et al, 2002)
  • involved in de novo synthesis of placental estrogens but may contribute to the clearance of estrogen sulfates from foetal circulation (Ugele et al, 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text organic anion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS