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FLASH GENE
Symbol SLCO2A1 contributors: shn - updated : 05-09-2010
HGNC name solute carrier organic anion transporter family, member 2A1
HGNC id 10955
Corresponding disease
PHTO2 primary hypertrophic osteoarthropathy 2
Location 3q22.2      Physical location : 133.651.541 - 133.748.920
Synonym name
  • solute carrier family 21 (prostaglandin transporter), member 2
  • prostaglandin transporter
  • solute carrier family 21 (prostaglandin transporter), member 2
  • solute carrier family 21 member 2
  • solute carrier organic anion transporter family member 2A1
  • organic anion transporter 2A1
  • prostaglandin transporter
  • Synonym symbol(s) PGT, OATP2A1, SLC21A2
    DNA
    TYPE functioning gene
    STRUCTURE 97.38 kb     14 Exon(s)
    regulatory sequence Promoter (TATA box)
    Binding site   cAMP
    motif
    text structure two Sp.1 sequences
    MAPPING cloned Y linked N status confirmed
    Map cen - D3S3713 - D3S3657 - SLCO2A1 - D3S3684 - D3S3637 - qter
    Physical map
    LOC344568 3q22.1 similar to proteasome (prosome, macropain) 26S subunit, ATPase 2; Proteasome (prosome, macropain) 26S subunit, ATPase LOC391577 3 similar to ribosomal protein L7 ACPP 3q21.3-q23 acid phosphatase, prostate LOC131039 3q22.1 similar to Saccharomyces cerevisiae Nip7p homolog RME8 3q22.1 RME8 protein FLJ12592 3q22.1 putative acyl-CoA dehydrogenase CCRL1 3q22 chemokine (C-C motif) receptor-like 1 UBE1DC1 3q22 ubiquitin-activating enzyme E1-domain containing 1 NPHP3 3q22.1 nephronophthisis 3 (adolescent) MGC3040 3q21 hypothetical protein MGC3040 BFSP2 3q21.2q22.3 beaded filament structural protein 2, phakinin MGC2848 3q22.1 hypothetical protein MGC2848 LOC391578 3 similar to MAF1 homolog; MAF1 homolog (yeast) H41 3q22.1 hypothetical protein H41 TOPBP1 3q22.1 topoisomerase (DNA) II binding protein LOC391579 3 similar to RIKEN cDNA 1300017J02 TF 3q21 transferrin PRO2086 3q22.1 PRO2086 protein APMCF1 3q22.1 PRO2086 protein RAB6B 3q22.2 RAB6B, member RAS oncogene family FLJ22173 3q22.1 hypothetical protein FLJ22173 SLCO2A1 3q21 solute carrier organic anion transporter family, member 2A1 RYK 3q22 RYK receptor-like tyrosine kinase AMOTL2 3q21-q22 angiomotin like 2 DKFZP566D193 3q22.1 DKFZP566D193 protein FLJ13386 3q22.1 hypothetical protein FLJ13386 FLJ33207 3q22.1 hypothetical protein FLJ33207 EPHB1 3q21-q23 EphB1
    RNA
    TRANSCRIPTS type messenger
    text several transcripts (Lu)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4234 - 643 choroid/RPE-complex and in the ciliary body Kraft et al, 2010
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
     liver   highly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   moderately
     thymus   moderately
    Nervousbrain   lowly
    Reproductivefemale systemplacenta  moderately
     female systemovary  highly
     male systemprostate  highly
     male systemtestis  highly
    Respiratorylung   moderately
    Urinarykidney   highly
    Visualeyeanterior segment  highly
     eyeanterior segmentcornea highly
     eyeanterior segmentconjunctiva highly
     eyeanterior segmentiris highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningneuroepithelium highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, brain, lung, liver, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative twelve transmembrane domains
  • N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Slco2a1, Rattus norvegicus
    ortholog to slco2a1, Danio rerio
    ortholog to SLCO2A1, Pan troglodytes
    ortholog to slco2a1, Mus musculus
    Homologene
    FAMILY organic anion transporting polypeptide (OATP) family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be mediating the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation
  • involved in the clearance of latanoprost acid from the aqueous humor and may thereby influence the bioavailability of latanoprost in patients (Kraft et al, 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHTO2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS