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FLASH GENE
Symbol SLCO2A1 contributors: shn - updated : 07-10-2019
HGNC name solute carrier organic anion transporter family, member 2A1
HGNC id 10955
Corresponding disease
CEAS chronic enteropathy associated with SLCO2A1 gene
PHTO2 primary hypertrophic osteoarthropathy 2
Location 3q22.2      Physical location : 133.651.541 - 133.748.920
Synonym name
  • solute carrier family 21 (prostaglandin transporter), member 2
  • prostaglandin transporter
  • solute carrier family 21 (prostaglandin transporter), member 2
  • solute carrier family 21 member 2
  • matrin F/G 1
  • organic anion transporter 2A1
  • prostaglandin transporter
  • Synonym symbol(s) PGT, OATP2A1, SLC21A2, MATR1, PHOAR2
    DNA
    TYPE functioning gene
    STRUCTURE 97.38 kb     14 Exon(s)
    regulatory sequence Promoter (TATA box)
    Binding site   cAMP
    motif
    text structure two Sp.1 sequences
    MAPPING cloned Y linked N status confirmed
    Map cen - D3S3713 - D3S3657 - SLCO2A1 - D3S3684 - D3S3637 - qter
    RNA
    TRANSCRIPTS type messenger
    text several transcripts (Lu)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4234 - 643 choroid/RPE-complex and in the ciliary body 2006 16339169
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
     liver   highly
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   moderately
     thymus   moderately
    Nervousbrain   lowly
    Reproductivefemale systemplacenta  moderately
     female systemovary  highly
     male systemprostate  highly
     male systemtestis  highly
    Respiratorylung   moderately
    Urinarykidney   highly
    Visualeyeanterior segment  highly
     eyeanterior segmentcornea highly
     eyeanterior segmentconjunctiva highly
     eyeanterior segmentiris highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningneuroepithelium highly
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, brain, lung, liver, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative twelve transmembrane domains
  • N-glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Slco2a1, Rattus norvegicus
    ortholog to slco2a1, Danio rerio
    ortholog to SLCO2A1, Pan troglodytes
    ortholog to slco2a1, Mus musculus
    Homologene
    FAMILY organic anion transporting polypeptide (OATP) family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be mediating the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation
  • involved in the clearance of latanoprost acid from the aqueous humor and may thereby influence the bioavailability of latanoprost in patients (Kraft et al, 2010)
  • influences PGE2-mediated cellular pathways
  • is likely involved in PGE2-loading into intracellular acidic compartments, including light lysosomes
  • contributes to PGE2 secretion by macrophages via exocytosis induced by Ca(2+) influx, independently of PGE2 synthesis and metabolism
  • prostaglandin transporter that mediates the uptake and clearance of prostaglandins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cytoplasmic SLCO2A1 likely facilitates prostaglandin E2 (PGE2) loading into suitable intracellular compartment(s) for efficient exocytotic PGE2 release from Colorectal cancer cells exposed to oxidative stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHTO2 , CEAS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    SLCO1B3, SLCO2A1, SLC33A1 and SLCO4A1 are up-regulated in pancreatic adenocarcinoma (
    Susceptibility to digital clubbing and early-onset colon neoplasia
    Variant & Polymorphism other
  • heterozygous nonsense mutation (G104X) associated with digital clubbing and early-onset colon neoplasia
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    blockade of OATP2A1 is an additional pharmacologic strategy to improve colon cancer outcomes
    ANIMAL & CELL MODELS