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FLASH GENE
Symbol SLCO1C1 contributors: SGE/npt - updated : 09-07-2010
HGNC name solute carrier organic anion transporter family, member 1C1
HGNC id 13819
Location 12p12.2      Physical location : 20.848.288 - 20.906.318
Synonym name
  • solute carrier family 21 (organic anion transporter), member 14
  • organic anion transporting polypeptide 14
  • organic anion transporter polypeptide-related protein 5
  • organic anion transporter F
  • Synonym symbol(s) OATP-F, SLC21A14, OATP1, OATP1C1, OAT-RP-5, OATP14
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with OATP-A, OATP-C, OATP8
    STRUCTURE 57.92 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3381 - 712 - Pizzagalli (2002)
  • isoform 2
  • - - 3471 - 730 - Pizzagalli (2002)
  • isoform 1
  • - - 3221 - 663 - Pizzagalli (2002)
  • isoform 3
  • - - 3188 - 612 - Pizzagalli (2002)
  • isoform 4
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea  
    Nervousbraindiencephalonhypothalamus  
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    ReproductiveLeydig cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one Kazal-like domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Slco1c1 (84.1pc)
    homolog to rattus Slco1c1 (84.8pc)
    Homologene
    FAMILY
  • organic anion transporter family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an important role in the disposition of thyroid hormones in brain and testis
  • transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues
  • can transport fenamates (non steroidal antiinflammatory drugs) into brain barrier cells (Westholm 2009)
  • high affinity for thyroxine, tri-iodothyronine and reverse tri-iodothyronine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text transport ions
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may function as a pair with SLC16A2 to transport T4 from the blood into the cerebrospinal fluid and to efflux thyroid hormones to their inatives metabolites from the cerebral spinal fluid to blood (Roberts 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism polymorphism of the gene may be associated with fatigue and depression in patients suffering from hypothyroidism (Van der Deure 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS