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FLASH GENE
Symbol SLCO1B1 contributors: mct - updated : 08-02-2011
HGNC name solute carrier organic anion transporter family, member 1B1
HGNC id 10959
Location 12p12.2      Physical location : 21.284.127 - 21.392.728
Synonym name
  • liver specific transporter 1
  • solute carrier family 21 (organic anion transporter), member 6
  • sodium-independent organic anion-transporting polypeptide 2
  • Synonym symbol(s) LST1, OATP2, OATPC, OAT6, SLC21A6, OATP1B1, MGC133282
    DNA
    TYPE functioning gene
    STRUCTURE 108.60 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    AEBP2 12p12.3 AE(adipocyte enhancer)-binding protein 2 LOC341473 12p12.3 similar to T-complex protein 1, alpha subunit (TCP-1-alpha) (CCT-alpha) PDE3A 12p12 phosphodiesterase 3A, cGMP-inhibited SLCO1C1 12p12.3 solute carrier organic anion transporter family, member 1C1 SLCO1B3 12p12 solute carrier organic anion transporter family, member 1B3 LST-3 12p12.3 liver-specific organic anion transporter 3 SLCO1B1 12p solute carrier organic anion transporter family, member 1B1 SLCO1A2 12p12 solute carrier organic anion transporter family, member 1A2 IAPP 12p12.3-p12.2 islet amyloid polypeptide FLJ22028 12p12.3 hypothetical protein FLJ22028 RECQL 12p12-p11 RecQ protein-like (DNA helicase Q1-like) CGI-141 12p12.3 CGI-141 protein MGC10946 12p12.3 hypothetical protein MGC10946 GYS2 12p12.2 glycogen synthase 2 (liver) LDHB 12p12.2-p12.1 lactate dehydrogenase B KCNJ8 12p11.23 potassium inwardly-rectifying channel, subfamily J, member 8 ABCC9 12p12.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 CMAS 12p13.2 cytidine monophosphate N-acetylneuraminic acid synthetase SIAT8A 12p12.3-p12.2 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) KIAA0528 12p12.2 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) EKI1 12p12.3 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2800 - 691 - 2000 10779507
    - splicing 4800 - - only in liver, basolateral membranes of hepatocytes 2000 10779507
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   moderately
    Digestiveliver     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains, and transmembrane domain 10 (TM10) is critical for its function
  • N-glycosylation sites
  • two potential phosphorylation sites
  • conserved AAs R57, K361 and R580 seem to be part of the substrate binding sites and/or translocation pathways
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans y32f6b1
    Homologene
    FAMILY
  • SLC21A superfamily of solute carriers
  • organo anion transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text expressed on the sinusoidal membrane of human hepatocytes
    basic FUNCTION
  • transport of conjugated steroids (17beta glucoronosyl estradid, 3(H) estrone-3-sulfate, eicosanoids and thyroid hormones)
  • transporter of exogenous substance : bromosulfphophtalein, and predominantly involved in hepatic uptake of pravastatin
  • playing a role in prevention of hyperbilirubinemia by facilitating entry of unconjugated bilirubin in hepatocytes
  • involved in the hepatocellular uptake of a variety of endogenous and xenobiotic substances and drugs
  • plays an important role in the hepatic uptake of bile acids
  • plays a role in the pharmacokinetics of olmesartan, and the co-administration of olmesartan does not affect the pharmacokinetics of pravastatin or its metabolite
  • genetically polymorphic influx transporter which mediates the hepatic uptake of many endogenous compounds and xenobiotics
  • plays a major role in the hepatic uptake of drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text organic anion transport
    PATHWAY
    metabolism porphyrin/heme
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of porphyrins with SLCO1B1, and tetrapyrroles are transported by SLCO1B1
  • cell & other
    REGULATION
    Other regulated by HNF1A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to interindividual variability in the pharmacokinetics of olmesartan
  • to risk of statin-induced myopathy
  • Variant & Polymorphism other
  • polymorphism L193R, mutant protein SLC21A6-L193R was retained intracellularly, and this single amino acid exchange abolished transport function
  • polymorphism could contribute to the interindividual variability in the pharmacokinetics of olmesartan
  • common variants are strongly associated with an increased risk of statin-induced myopathy
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS