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FLASH GENE
Symbol SLCO1A2 contributors: - updated : 16-04-2005
HGNC name solute carrier organic anion transporter family, member 1A2
HGNC id 10956
Location 12p12      Physical location : 21.417.534 - 21.548.371
Synonym name solute carrier family 21 (organic anion transporter), member 3
Synonym symbol(s) OATP1, OATPA, OATP, SLC21A3, OATP-A, OATP1A2
DNA
TYPE functioning gene
STRUCTURE 49.00 kb     13 Exon(s)
MAPPING cloned Y linked   status provisional
Physical map
LOC341473 12p12.3 similar to T-complex protein 1, alpha subunit (TCP-1-alpha) (CCT-alpha) PDE3A 12p12 phosphodiesterase 3A, cGMP-inhibited SLCO1C1 12p12.3 solute carrier organic anion transporter family, member 1C1 SLCO1B3 12p12 solute carrier organic anion transporter family, member 1B3 LST-3 12p12.3 liver-specific organic anion transporter 3 SLCO1B1 12p solute carrier organic anion transporter family, member 1B1 SLCO1A2 12p12 solute carrier organic anion transporter family, member 1A2 IAPP 12p12.3-p12.2 islet amyloid polypeptide FLJ22028 12p12.3 hypothetical protein FLJ22028 RECQL 12p12-p11 RecQ protein-like (DNA helicase Q1-like) CGI-141 12p12.3 CGI-141 protein MGC10946 12p12.3 hypothetical protein MGC10946 GYS2 12p12.2 glycogen synthase 2 (liver) LDHB 12p12.2-p12.1 lactate dehydrogenase B KCNJ8 12p11.23 potassium inwardly-rectifying channel, subfamily J, member 8 ABCC9 12p12.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 CMAS 12p13.2 cytidine monophosphate N-acetylneuraminic acid synthetase SIAT8A 12p12.3-p12.2 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) KIAA0528 12p12.2 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) EKI1 12p12.3 sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2720 - 670 - Kullak-Ublik
- splicing 2740 - 670 - Kullak-Ublik
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivemale systemtestis   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane domains
  • eight potential glycosylation sites
  • six potential protein kinase C phosphorylation sites
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Slc21a7
    Homologene
    FAMILY solute carrier family 21, organic anion
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION involved in the transport of thyroid hormones,taurocholic acid and pravastatin (hepatic uptake of the liver-specific hydroxymethyl-glutaryl CoA reductase inhibitor)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text transepithelial organic anion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS