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FLASH GENE
Symbol SLC9C1 contributors: mct - updated : 19-02-2018
HGNC name solute carrier family 9 member C1
HGNC id 31401
Location 3q13.2      Physical location : -
Synonym name
  • solute carrier family 9, isoform 10
  • sperm-specific Na(+)/H(+) exchanger
  • sperm-specific sodium proton exchanger
  • Synonym symbol(s) NHE, NHE-10, SLC9A10, sperm-NHE
    DNA
    TYPE functioning gene
    STRUCTURE 153.36 kb     30 Exon(s)
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 4025 - 1129 - 2012 23000155
    29 - 4169 - 1177 - 2012 23000155
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas    
    Reproductivefemale systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY Na(+)/H(+) exchanger family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • may be playing an important role in colonic sodium absorption
  • involved in ph regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions
  • is critical for expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) and this complex efficiently modulates intracellular pH and bicarbonate levels to facilitate sperm motility regulation
  • transmembrane protein responsible for alkalinization and control of intracellular acidosis by the removal of hydrogen and influx of sodium
  • plays important roles in regulation of protection beta-cells against strong acidification and intracellular hydrogen overload
  • participate in the regulation of cytosolic and organellar pH as well as cell volume. In the intestine and kidney
  • role in maintaining H(+) homeostasis and intricate roles in the regulation of neuronal function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    linked to the pathogenesis of several diseases, including essential hypertension, diabetes, congenital secretory diarrhea, tissue damage caused by ischemia/reperfusion and oncogenic transformation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    development of drugs that modulate the activity of SLC9C1 could, in the future, become new strategies for the treatment of diabetes or its chronic complications.
    ANIMAL & CELL MODELS
  • disruption of the sNHE gene in mice resulted in absolute male infertility associated with a complete loss of sperm motility