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FLASH GENE
Symbol SLC9A9 contributors: mct - updated : 28-06-2013
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 9
HGNC id 20653
Corresponding disease
AUTS16 autism spectrum disorder, 13
Location 3q24      Physical location : 142.984.064 - 143.567.373
Synonym name
  • solute carrier family 9 (sodium/hydrogen exchanger), isoform 9
  • sodium/proton exchanger NHE9
  • putative protein product of Nbla00118
  • Na(+)/H(+) exchanger 9
  • Synonym symbol(s) FLJ35613, NHE9, Nbla00118
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 583.28 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    TRIM42 3q23-24 tripartite motif-containing 42 LOC391583 3 similar to 60S ribosomal protein L23a FLJ10618 3q23 hypothetical protein FLJ10618 SSB4 3q23 SPRY domain-containing SOCS box protein SSB-4 FLJ23751 3q23 hypothetical protein FLJ23751 FLJ35036 3q23 hypothetical protein FLJ35036 LOC391584 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RASA2 3q22-q23 RAS p21 protein activator 2 LOC389153 3 LOC389153 LOC391585 3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) RNF7 3q22-q24 ring finger protein 7 GPRK7 3q21-q24 G protein-coupled receptor kinase 7 ATP1B3 3q22-q23 ATPase, Na+/K+ transporting, beta 3 polypeptide TFDP2 3q23 transcription factor Dp-2 (E2F dimerization partner 2) MGC40579 3q23 hypothetical protein MGC40579 SEP1 3q23 strand-exchange protein 1 ATR 3q22-q24 ataxia telangiectasia and Rad3 related PLS1 3q23 plastin 1 (I isoform) TRPC1 3q22-q24 transient receptor potential cation channel, subfamily C, member 1 PCOLCE2 3q21-q24 procollagen C-endopeptidase enhancer 2 PAQR9 3q23 progestin and adipoQ receptor family member IX SR140 3q23-q24 progestin and adipoQ receptor family member IX LOC389154 3 LOC389154 CHST2 3q24 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 PBXP1 3q22-q23 pre-B-cell leukemia transcription factor pseudogene 1 SLC9A9 3p14 solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 LOC257039 3q24 similar to ribosomal protein S17 MGC33365 3q24 hypothetical protein MGC33365 GM2AP 3q21-q25 GM2 ganglioside activator protein pseudogene LOC389156 3 similar to 60S ribosomal protein L21 PLOD2 3q23-q24 procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2 PLSCR4 3q24 phospholipid scramblase 4 LOC389157 3 similar to CG32056-PA PLSCR2 3q24 phospholipid scramblase 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3647 - 645 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
     brainhindbrainmedulla oblongata highlyHomo sapiens
     brainbasal nucleistriatum   Homo sapiens
     brainforebraincerebral cortex highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text brain, heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten transmembrane domains
  • a binding region delineated to the central region of the C terminus
  • HOMOLOGY
    intraspecies homolog to SLC9A6,SLC9A7
    Homologene
    FAMILY
  • monovalent cation:proton antiporter 1 (CPA1) transporter family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text in late recycling endosomes
    basic FUNCTION
  • may be playing a role in neuronal cell function
  • potentially implicated in human attention deficit/hyperactivity disorder (ADHD), autism
  • membrane protein that regulates the luminal pH of the recycling endosome, an essential organelle for synaptic transmission and plasticity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with RACK1 (receptor for activated C kinase 1), a cytoplasmic scaffold protein
  • interactions of SLC9A9 with two molecules: calcineurin homologous protein (CHP1) and receptor for activated C-kinase 1 (RACK1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTS16
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS