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FLASH GENE
Symbol SLC9A8 contributors: npt/mct - updated : 23-08-2010
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 8
HGNC id 20728
Location 20q13.13      Physical location : 48.429.249 - 48.508.772
Synonym name
  • solute carrier family 9 (sodium/hydrogen exchanger), isoform 8
  • Na(+)/H(+) exchanger 8
  • sodium/hydrogen exchanger 8
  • Synonym symbol(s) NHE8, KIAA0939, DKFZp686C03237, FLJ42500, MGC138418
    DNA
    TYPE functioning gene
    STRUCTURE 79.52 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • activated by Sp3 transcriptional factor, and TNF inhibits SLC9A8 expression by reducing Sp3 interaction at the minimal promoter region of the human gene (Xu 2009)
  • MAPPING cloned Y linked N status provisional
    Physical map
    PREX1 20q12-q13 potassium voltage-gated channel, subfamily G, member 1 ARFGEF2 20q13.13 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) SNAP23P 20 synaptosomal-associated protein, 23kDa pseudogene CSE1L 20q13 CSE1 chromosome segregation 1-like (yeast) STAU 20q13.1 staufen, RNA binding protein (Drosophila) ARPC3B 20q13.13 actin related protein 2/3 complex, subunit 3B, 21kDa DDX27 20q13.13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 KIAA1404 20q13.13 KIAA1404 protein KCNB1 20q13.1 potassium voltage-gated channel, Shab-related subfamily, member 1 PTGIS 20q13.1-q13.3 prostaglandin I2 (prostacyclin) synthase B4GALT5 20q13.1-q13.2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 SNRPFP1 20 small nuclear ribonucleoprotein polypeptide F pseudogene 1 SLC9A8 20q13.13 solute carrier family 9 (sodium/hydrogen exchanger), isoform 8 SPATA2 20q13.1-q13.2 spermatogenesis associated 2 ZNF313 20q13.13 zinc finger protein 313 LOC391256 20 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SNAI1 20q13.2 snail homolog 1 (Drosophila) LOC149738 20q13.13 hypothetical LOC149738 UBE2V1 20q13.2 ubiquitin-conjugating enzyme E2 variant 1 CEBPB 20q13.1 CCAAT/enhancer binding protein (C/EBP), beta COX6CP2 20 cytochrome c oxidase subunit VIc pseudogene 2 PTPN1 20q13.1-q13.2 protein tyrosine phosphatase, non-receptor type 1 LOC200230 20q13.13 similar to KIAA0386 C20orf175 20 chromosome 20 open reading frame 175 RPL36P2 20q13.1 ribosomal protein L36 pseudogene 2 PARD6B 20q13.13 par-6 partitioning defective 6 homolog beta (C. elegans) BCAS4 20q13.13-q13.2 breast carcinoma amplified sequence 4 TMSL6 20 thymosin-like 6 ADNP 20q13.3-q13.2 activity-dependent neuroprotector PSMD10P 20q13.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene DPM1 20q13.13 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit MOCS3 20 molybdenum cofactor synthesis 3 KCNG1 20q13 potassium voltage-gated channel, subfamily G, member 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 6255 - 581 - Xu (2008)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestineduodenum  
     intestinelarge intestinecolon  
     intestinesmall intestinejejunum  
     intestinesmall intestineileum  
     stomach    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell
    urinarykidney
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, perinatal
    Text maturational increase in postnatal brush-border membrane (BBM) vesicle SLC9A3 protein abundance and decrease in SLC9A8 protein abundance (Gattineni 2008)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • monovalent cation:proton antiporter 1 (CPA1) transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • expressed on the apical membrane of intestinal epithelial cells (Xu 2010)
  • basic FUNCTION
  • may be involved in regulation of pH and monovalent cation concentration (Nakamura 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by glucocorticoids which inhibit SLC9A8 gene expression by increasing PAX5 binding on SLC9A8 gene promoter, suggesting an important role for PAX5 during intestinal maturation (Xu 2010)
    thyroid hormone (plays a potential role in the developmental isoform change from SLC9A8 to SLC9A3 and decreases SLC9A8 activity (Gattineni 2008)
    repressed by EGF (EGF inhibits SLC9A8 gene expression through reducing its basal transcription, suggesting an important role of EGF in regulating NHE expression during intestinal maturation) (Xu 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    decreased Slc9a8 isoform expression and defective acidification in proximal convoluted tubules of senile rats (Fiori 2009)