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FLASH GENE
Symbol SLC9A5 contributors: mct/npt - updated : 19-02-2018
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 5
HGNC id 11078
Location 16q22.1      Physical location : 67.282.854 - 67.306.093
Synonym name
  • antiporter (exchanger), Na+/H+
  • solute carrier family 9 (sodium/hydrogen exchanger), isoform 5
  • Synonym symbol(s) NHE5
    DNA
    TYPE functioning gene
    STRUCTURE 23.24 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    Map cen - D16S419 - D16S408 - D16S494 - D16S514 - D16S421 - SLC9A5 - D16S512 - D16S518 - D16S516 - qter
    Authors Klanke (95)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3745 - 896 - Diering (2009)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Lymphoid/Immunespleen    
    Nervousbraindiencephalonhypothalamus predominantly Homo sapiens
    Reproductivefemale systembreastmammary gland  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten (? twelve) transmembrane segments (TM)
  • with a large acidic cytoplasmic C terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • solute carrier protein family 9
  • monovalent cation:proton antiporter 1 (CPA1) transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • brain-enriched Na(+)/H(+) exchanger that dynamically shuttles between the plasma membrane and recycling endosomes (Diering (2009)
  • not only resides in the plasma membrane but also accumulates in recycling vesicles by means of clathrin-mediated endocytosis (Szabo 2005)
  • basic FUNCTION
  • involved in intracellular pH regulation and cell volume
  • playing an important role in signal transduction
  • may play important roles in ion homeostasis and cell-volume regulation (Onishi 2007)
  • brain-enriched Na(+)/H(+) exchanger, serving as a mechanism that acutely controls the local pH environment (Diering 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds to the N- and C-terminal cytosolic extensions of SCAMP2 (Diering 2009)
  • cell & other
    REGULATION
    Other dynamically regulated by phosphatidylinositol 3-kinase and by the state of F-actin assembly
    regulated by GNB2L1 (Onishi 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS