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FLASH GENE
Symbol SLC9A4 contributors: mct - updated : 19-02-2018
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 4
HGNC id 11077
Location 2q12.1      Physical location : 103.089.761 - 103.150.430
Synonym name
  • solute carrier family 9 (sodium/hydrogen exchanger), isoform 4
  • antiporter (exchanger), Na+/H+
  • Synonym symbol(s) NHE4, DKFZp313B031
    DNA
    TYPE functioning gene
    STRUCTURE 60.67 kb     12 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4174 - 798 - 2003 12576672
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   predominantly Homo sapiens
     pharynx    
    Reproductivefemale systemuterus   
    Urinarykidney   predominantly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten (? twelve) transmembrane segments
  • a large acidic cytoplasmic C terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • solute carrier protein family 9, sodium/hydrogen exchange
  • Na+/H+ exchangers (NHEs) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in intracellular pH regulation and cell volume
  • implicated in several pathophysiological conditions, including essential hypertension and congenital secretory diarrhea
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calcineurin homologous protein (CHP) acts as a crucial cofactor for NHE activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS