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FLASH GENE
Symbol SLC8B1 contributors: mct/npt - updated : 23-12-2016
HGNC name solute carrier family 8 member B1
HGNC id 26175
Location 12q24.13      Physical location : -
Synonym name
  • Na(+)/Ca(2+) lithium exchanger
  • solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
  • sodium/potassium/calcium exchanger 6, mitochondrial
  • TBK1-associated protein in endolysosomes
  • Synonym symbol(s) NCLX, NCKX6, FLJ22233, SLC24A6, TAPE
    DNA
    TYPE functioning gene
    STRUCTURE 36.38 kb     16 Exon(s)
    regulatory sequence alternative promoter
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2993 70 584 - 2014 24898248
  • retained within the endoplasmic reticulum
  • also called SLC24A6L
  • - - 3423 55 528 - 2014 24898248
  • exhibited K(+)-dependent Na+/Ca2+ exchange activity
  • present at the plasma membrane
  • also called SLC24A6S
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Lymphoid/Immunelymph node    
    Reproductivefemale systemovary   
     male systemtestis   
    Urinarybladder   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two large hydrophilic loops
  • two sets of transmembrane spanning segments (TMs)
  • the first large hydrophilic loop is located extracellularly at the N-terminus
  • the other is cytoplasmic and separates the two sets of TMs (Kinjo 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • sodium/potassium/calcium exchanger family
  • SLC24A subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text
  • Na(+)/Ca(2+) exchanger NCLX is enriched in mitochondria, where it is localized to the cristae (Palty 2010)
  • localized in the inner mitochondria membrane
  • basic FUNCTION
  • playing an important role for K(+)-dependent Na+/Ca2+ exchange in maintaining cellular Ca2+ homeostasis in diverse tissues and cell types
  • catalyzes active Li(+)/Ca(2+) exchange, thereby explaining the exchange of these ions in mammalian tissues (Palty 2004)
  • polytopic membrane protein that plays a critical role in Ca(2+) homeostasis in retinal rod and cone photoreceptors (Kinjo 2003)
  • catalyzes active Li(+)/Ca(2+) exchange, thereby explaining the exchange of these ions in mammalian tissues
  • playing a role in mediating agonist-stimulated [Ca2+]cyt and thereby vascular tone (Dong 2006)
  • long-sought mitochondrial Na(+)/Ca(2+) exchanger (Palty 2010)
  • its expression is linked to mitochondria Na(+)/Ca(2+) exchange matching the functional fingerprints of the putative mitochondrial Na(+)/Ca(2+) exchanger
  • mitochondrial Na(+)/Ca(2+) exchanger, SLC8B1, shapes glucose-dependent mitochondrial and cytosolic Ca(2+) signals thereby regulating the temporal pattern of insulin secretion in beta cells
  • in the heart and many other mammalian tissues, efficiently mediates Li(+)/Ca(2+) exchange (as well as Na(+)/Ca(2+) exchange)
  • by meditating astrocytic mitochondrial Na(+)/Ca(2+) exchange, links between mitochondria and plasma membrane Ca(2+) signaling, thereby modulating cytoplasmic Ca(2+) transients required to control a diverse array of astrocyte functions
  • is a novel molecule to regulate automaticity of cardiomyocytes via modulating SR Ca(2+) handling
  • mediates the mitochondrial Na(+) influx and is tuned to sense the tetrodotoxin (TTX)-sensitive cytosolic Na(+) responses
  • SLC8B1 but not LETM1, mediates Ca(2+) extrusion from mitochondria
  • by controlling the duration of matrix Ca(2+) elevations, NCLX contributes to the regulation of NAD(P)H production and to the conversion of Ca(2+) signals into redox changes
  • in lymphocytes, is essential for refilling the endoplasmic reticulum Ca(2+) stores required for antigen-dependent signaling
  • is emerging as a hub for integrating glucose-dependent Na(+) and Ca(2+) signaling in pancreatic beta cells
  • cytosolic Na(+)-dependent mitochondrial Ca(2+) efflux transporter, SLC8B1, regulates B lymphocyte chemotaxis
  • is pivotal for B lymphocyte motility and chemotaxis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mitochondrial Na(+) influx via SLC8B1 is antagonized by Na(+) efflux, which is mediated by the mitochondrial SLC9A1
  • loss of PINK1 function, implicated in Parkinson disease, inhibits the mitochondrial Na(+)/Ca(2+) exchanger (SLC8B1), leading to impaired mitochondrial Ca(2+) extrusion
  • SLC8B1 activity was, however, fully rescued by activation of the protein kinase A (PRKACA) pathway
  • cell & other
    REGULATION
    repressed by strongly by zinc, although it does not transport this cation (Palty 2004)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS