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FLASH GENE
Symbol SLC7A8 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
HGNC id 11066
Location 14q11.2      Physical location : 23.594.505 - 23.652.849
Synonym name
  • integral membrane protein E16H
  • L-type amino acid transporter 2
  • integral membrane protein E16H
  • large neutral amino acids transporter small subunit 2
  • Synonym symbol(s) LAT2, LPI-PC1
    DNA
    TYPE functioning gene
    STRUCTURE 58.35 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D4S72 - D4S550 - D4S283 - TRA@ - DAD1 - SLC7A7 - SLC7A8 - D4S990 - MYH7 - qter
    Authors Bassi (99)
    Physical map
    ABHD4 14q11.1 abhydrolase domain containing 4 OR6J1P 14p12 olfactory receptor, family 6, subfamily J, member 1 pseudogene RPL26P2 14 ribosomal protein L26 pseudogene 2 LOC390461 14 similar to olfactory receptor C6 OXA1L 14q11.2 oxidase (cytochrome c) assembly 1-like SLC7A7 14q11.2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 MRPL52 14q11.2 mitochondrial ribosomal protein L52 MMP14 14q11.2 matrix metalloproteinase 14 (membrane-inserted) LRP10 14q11.2 low density lipoprotein receptor-related protein 10 FLJ38964 14q11.2 hypothetical protein FLJ38964 RNPC4 14q11.2 RNA-binding region (RNP1, RRM) containing 4 SKB1 14q11.2-q21 SKB1 homolog (S. pombe) C14orf94 14q11.1 chromosome 14 open reading frame 94 JUB 14q11.2 jub, ajuba homolog (Xenopus laevis) C14orf93 14q11.1 chromosome 14 open reading frame 93 PSMB5 14q11.2 proteasome (prosome, macropain) subunit, beta type, 5 LOC122706 14q11.2 similar to RIKEN cDNA 5830406J20 CDH24 14q11.2 cadherin-like 24 ACINUS 14q11.2 apoptotic chromatin condensation inducer in the nucleus C14orf119 14q11.2 chromosome 14 open reading frame 119 CEBPE 14q11.2 CCAAT/enhancer binding protein (C/EBP), epsilon SLC7A8 14q11.2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 RPL39P2 14 ribosomal protein L39 pseudogene 2 HMGN2P 14 high-mobility group nucleosomal binding domain 2 pseudogene KIAA1443 14q11.2 KIAA1443 LOC90673 BCL2L2 14q11.2-q12 BCL2-like 2 PABPN1 14q11.2-q13 poly(A) binding protein, nuclear 1 SLC22A17 14q11.2 solute carrier family 22 (organic cation transporter), member 17 EFS 14q11.2-q12 embryonal Fyn-associated substrate IL17E 14q11.2 interleukin 17E CKLFSF5 14q11.2 chemokine-like factor super family 5 MYH6 14q11.2 myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) MYH7 14q11.2 myosin, heavy polypeptide 7, cardiac muscle, beta C14orf120 14q11.2 chromosome 14 open reading frame 120
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 4237 - 535 - Park (2005)
    9 - 3145 - 332 - Park (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Urinarykidneytubuleconvoluted tubuleproximal tubulehighly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • two conserved cysteine residues between TM3 and TM4, the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • amino acid-polyamine-organocation (APC) superfamily
  • L-type amino acid transporter (LAT) family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • coexist with SLC16A10 in the basolateral membrane of the renal proximal tubules (Park 2005)
  • expressed in various tissues, including the intestinal wall, blood-brain barrier, and kidney (Del Amo 2008)
  • basic FUNCTION
  • involved in epithelial aminoacid (re)absorption, broad scope neutral aminoacids transporter
  • contribute to the renal reabsorption of neutral amino acids in the basolateral domain of epithelial proximal tubule cells (Park 2005)
  • play essential roles in the reabsorption of neutral amino acids from the epithelial cells to the blood stream in the kidney (Park 2005)
  • with SLC7A5, functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids (Omidi 2008)
  • may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism (Capelo 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein 4F2hc/CD98 at the basolateral membrane to form a complex mediating y+L-type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
  • system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS