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FLASH GENE
Symbol SLC7A7 contributors: mct - updated : 22-04-2011
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
HGNC id 11065
Corresponding disease
LPI lysinuric protein intolerance
Location 14q11.2      Physical location : 23.242.433 - 23.289.014
Synonym name
  • lysophospholipid lysophosphatidylinositol
  • Synonym symbol(s) LPI, Y+LAT1, LAT3
    DNA
    TYPE functioning gene
    STRUCTURE 46.58 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    text structure
  • an alternative, TATA-box-containing promoter that plays a role in the tissue-specific regulation of the SLC7A7 gene expression (downstream promoter in front of exon 2 seems to be active in tissues with strong defects in the function of the transporter in patients with LPI)
  • AluY sequence localized at the 3' region
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2287 - 511 - 2000 10737982
    11 - 2152 - 511 - 2000 10737982
    10 - 2531 - 511 - 2000 10737982
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
     spleen   highly
    Digestiveintestinesmall intestine  highly
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • two conserved cysteine residues between TM3 and TM4
  • the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 7, cationic amino-acid
  • heterodimeric amino acid transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane of epithelial cells
    basic FUNCTION
  • mediating y+L-type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
  • light chain of the heterodimeric carrier responsible for cationic amino acid (CAA) transport across the basolateral membranes of epithelial cells in intestine and kidney
  • potentially a major contribution to the transport of cationic amino acids in pachytene spermatocytes and early spermatids
  • GPR55 and its endogenous ligand SLC7A7 play essential roles in the homoeostatic responses to stress signals in several mammalian tissues and cells including certain types of immune cells
  • role of SLC7A7 and its receptor GPR55 in cancer cells in activating an autocrine loop that regulates cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with the heavy chain 4F2hc, CD98 to form a complex of approximatly 135kDa, mediating y+L-type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
  • system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
  • DDHD1-SLC7A7-GPR55 axis may be involved in functions in the brain (
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interfering with SLC7A6
  • ligand of GPR55
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LPI
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • novel cancer biomarker
  • Therapy target
    ANIMAL & CELL MODELS