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FLASH GENE
Symbol SLC7A5 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
HGNC id 11063
Location 16q24.2      Physical location : 87.863.629 - 87.903.100
Synonym name
  • membrane protein E16 related
  • integral membrane protein E16
  • CD98 light chain
  • human cell surface glycoprotein 4F2 light chain
  • large neutral amino acids transporter small subunit 1
  • sodium-independent neutral amino acid transporter LAT1
  • y+ system cationic amino acid transporter
  • 4F2 light chain
  • CD98 light chain
  • Synonym symbol(s) D16S469E, MPE16, LAT1, CD98LC, 4F2LC, CD98, E16, CD98LC
    DNA
    TYPE functioning gene
    STRUCTURE 39.47 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388305 16 LOC388305 MGC15419 16q24.2 MGC15419 protein MAP1LC3B 16q24.1 microtubule-associated protein 1 light chain 3 beta BDG29 16q24.2 BDG-29 proten JPH3 16q24.3 junctophilin 3 DKFZp434G0522 16q24.3 hypothetical protein DKFZp434G0522 SLC7A5 16q24.3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 CA5A 16q24.3 carbonic anhydrase VA, mitochondrial BANP 16q24 carbonic anhydrase VA, mitochondrial LOC388306 16 LOC388306 LOC390747 16 similar to proline rich protein ZNF469 16q24 zinc finger protein 469 ZFPM1 16q24.3 zinc finger protein, multitype 1 LOC124245 16q24.3 hypothetical protein BC001584 IL17C 16q24 interleukin 17C CYBA 16q24.2 cytochrome b-245, alpha polypeptide MVD 16q24.2 mevalonate (diphospho) decarboxylase SNAI3 16q24.3 snail homolog 3 (Drosophila) MGC2647 16q24.3 hypothetical zinc finger protein MGC2647 LOC388307 16 similar to LOC348180 protein LOC348180 16q24.3 hypothetical protein LOC348180 KIAA0233 16q24.3 hypothetical protein LOC348180 FLJ40448 16q24.3 hypothetical protein FLJ40448
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4543 - 507 - Pffeifer (1999)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Digestiveintestinelarge intestinecolon highly
     liver    
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    Visualeyeretina  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, bone marrow, placenta, testis, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments (12TM)
  • cytoplasmic N and C termini with two conserved cysteine residues between TM3 and TM4,
  • the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Slc7a5
    Homologene
    FAMILY
  • amino acid-polyamine-organocation (APC) superfamily
  • L-type amino acid transporter (LAT) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text expressed in various tissues, including the intestinal wall, blood-brain barrier, and kidney (Del Amo 2008)
    basic FUNCTION
  • sodium-independent, high- affinity, transport of large neutral amino-acids, involved in cellular amino-acid uptake
  • AA permease-related protein which for surface expression and function requires formation of disulfide-linked heterodimers with the glycosylated heavy chain of the h4F2/CD98 surface antigen (Pfeiffer 1999)
  • playing a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina
  • with SLC7A8, functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids (Omidi 2008)
  • major transporter of tyrosine in human fibroblast cells (Vumma 21008)
  • may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism (Capelo 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein 4F2 heavy chain (CD98) to form a complex mediating L-type (sodium independent exchange) of large neutral amino acids transport
  • system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    has an important role to play in the metastatic process of variable neoplasms and its expression was significantly correlated with cell proliferation and angiogenesis (Kaira 2008)
    tumoral     --over  
    of SLC7A5 is a pathological factor to predict the prognosis in patients with resectable stage I pulmonary adenocarcinoma (Kaira 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • SLC7A5 expression is a promising pathological factor for predicting the prognosis in patients with resectable stage I non-small cell lung cancer (Imai 2009)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS