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FLASH GENE
Symbol SLC7A4 contributors: - updated : 31-08-2006
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
HGNC id 11062
Location 22q11.21      Physical location : 21.383.007 - 21.386.847
Synonym name
  • Ig heavy chain variable region
  • VH 3 family gene
  • Synonym symbol(s) CAAT3, CAT-4, CTR4, HCAT3, MGC129976, MGC129977, VH
    DNA
    TYPE functioning gene
    STRUCTURE 3.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ZNF74 22q11.21 zinc finger protein 74 (Cos52) SCARF2 22q11.21 scavenger receptor class F, member 2 FLJ14360 22q11.21 hypothetical protein FLJ14360 PCQAP 22q11.21 PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein LOC391300 22 similar to hypothetical protein FLJ20297 LOC343839 22q11.21 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC150207 22q11.21 hypothetical gene LOC150207 POM121L4P 22 POM121 membrane glycoprotein-like 4 pseudogene (rat) DKFZp434N035 22q11.21 hypothetical protein DKFZp434N035 PIK4CA 22q11.21 phosphatidylinositol 4-kinase, catalytic, alpha polypeptide SERPIND1 22q11.21 serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 SNAP29 22q11.21 synaptosomal-associated protein, 29kDa CRKL 22q11.21 v-crk sarcoma virus CT10 oncogene homolog (avian)-like FLJ30473 22q11.21-q11.22 hypothetical protein FLJ30473 LZTR1 22q11.1-q11.2 leucine-zipper-like transcriptional regulator, 1 THAP7 22q11.2 THAP domain containing 7 FLJ39582 22q11.2 hypothetical protein FLJ39582 MGC16703 22q11.22 alpha tubulin-like P2RXL1 22q11.21 purinergic receptor P2X-like 1, orphan receptor SLC7A4 22q11.21 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 LOC391301 22 similar to Tubulin alpha-3/alpha-7 chain (Alpha-tubulin 3/7) LOC388858 22 similar to Bcr protein LOC391302 22 hypothetical gene supported by AY358961; NM_014549 LOC376818 22q11.22 E2F transcription factor 6 pseudogene LOC388859 22 similar to Nucleosome binding protein 1 (Nucleosome binding protein 45) (NBP-45) (GARP45 protein) LOC388860 22 similar to Gamma-glutamyltranspeptidase 1 precursor (Gamma-glutamyltransferase 1) (CD224 antigen) LOC388861 22 similar to E2F transcription factor 6 isoform a LOC388862 22 LOC388862 LOC388863 22 similar to dJ831C21.3 (novel protein similar to DKFZP434P211 protein) LOC388864 22 similar to breakpoint cluster region isoform 1 LOC391303 22 similar to Nucleosome binding protein 1 (Nucleosome binding protein 45) (NBP-45) (GARP45 protein) LOC391304 22 similar to KIAA0649 gene product LOC391305 22 similar to Sushi domain (SCR repeat) containing KIAA1666  KIAA1666 protein HIC2 22q11.21 hypermethylated in cancer 2 LOC220686 22q11.22 hypothetical protein LOC220686 LOC150221 22q11.22 similar to hypothetical protein UBE2L3 22q11.22 ubiquitin-conjugating enzyme E2L 3 LOC150223 22q11.22 hypothetical protein LOC150223 FLJ36046 22q11.22 hypothetical protein FLJ36046 SDF2L1 22q11.22 stromal cell-derived factor 2-like 1 LOC388865 22 similar to RIKEN cDNA 2610318N02 PPIL2 22q11.22 peptidylprolyl isomerase (cyclophilin)-like 2
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
     braindiencephalonhypothalamus  
    Reproductivefemale systemplacenta   
     male systemtestis   
    Respiratorylung    
    Skin/Tegumentskin    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 13 transmembrane-spanning domains,
  • 5 potential N-glycosylation sites,
  • two putative protein kinase C phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY solute carrier family 7,cationic amino-acid
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION high affinity sodium independent, transporter of cationic aminoacids, but not sufficient to mediate alone in the plasma membrane the amino-acid transport
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in velo-cardio-facial syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS