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FLASH GENE
Symbol SLC7A11 contributors: - updated : 03-09-2005
HGNC name solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
HGNC id 11059
Location 4q28-q32      Physical location : 139.085.247 - 139.163.503
Synonym name cystine/glutamate transporter
Synonym symbol(s) XCT, CCBR1
DNA
TYPE functioning gene
STRUCTURE 71.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389223 4 similar to eukaryotic translation elongation factor 1 alpha 1-like 14 LOC391700 4 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC152620 4q28.3 similar to telomeric repeat binding factor 1 isoform 2; Telomeric repeat binding factor 1; telomeric repeat binding protein 1 LOC391701 4 similar to ribosomal protein S23 SLC7A11 4q28-q32 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 LOC152594 4q28.3 similar to ART-4 protein CCRN4L 4q28.3 CCR4 carbon catabolite repression 4-like (S. cerevisiae) ELF2 4q28 E74-like factor 2 (ets domain transcription factor) LOC389224 4 hypothetical gene supported by AK097799 OSAP 4q31.1 ovary-specific acidic protein NDUFC1 4q28.2-q28.3 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa TBDN100 4q31.1 transcriptional coactivator tubedown-100 RAB33B 4q28 RAB33B, member RAS oncogene family SET7 4q28 SET domain-containing protein 7 MGST2 4q28-q31 microsomal glutathione S-transferase 2 MAML3 4q28 mastermind-like 3 (Drosophila) SCOC 4q28.3 short coiled-coil protein LOC391702 4 similar to ribosomal protein L14; 60S ribosomal protein L14 CLGN 4q28.3-q31.1 calmegin LOC152586 4q31.1 similar to RIKEN cDNA 4933434I20 MGC10084 4q31.1 hypothetical protein MGC10084 UCP1 4q28-q31 uncoupling protein 1 (mitochondrial, proton carrier) KIAA0882 4q31.1 KIAA0882 protein LOC389225 4 LOC389225 LOC389226 4 similar to ring finger protein 130; g1-related zinc finger protein RNF150 4q31.1 ring finger protein 150 LOC389227 4 LOC389227 ZNF330 4q31.1-q31.2 LOC389227 LOC389228 4 similar to GRIK2 protein IL15 4q31 interleukin 15
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 mouthtongue   
 stomach   highly
Respiratoryrespiratory tractlarynx   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
twelve transmembrane domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Xct
Homologene
FAMILY
  • solute carrier family 7
  • amino acid permeases family
  • glycoprotein associated amino acid transporter (gpaat) subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in sodium-independent, high-affinity exchange of anionic amino acids with high specificity
  • for anionic form of cystine and glutamate
  • major genetic regulator of pheomelanin pigment in hair and melanocytes, with minimal or no effects on eumelanin, and controling the production of pheomelanin pigment
  • directly
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text cysteine/glutamate antiporter
    PATHWAY
    metabolism
    signaling
    a component
  • disulfide linked with SLC3A2/4F2HC
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS