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FLASH GENE
Symbol SLC7A11 contributors: - updated : 03-09-2005
HGNC name solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
HGNC id 11059
Location 4q28-q32      Physical location : 139.085.247 - 139.163.503
Synonym name cystine/glutamate transporter
Synonym symbol(s) XCT, CCBR1
DNA
TYPE functioning gene
STRUCTURE 71.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 mouthtongue   
 stomach   highly
Respiratoryrespiratory tractlarynx   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
twelve transmembrane domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Xct
Homologene
FAMILY
  • solute carrier family 7
  • amino acid permeases family
  • glycoprotein associated amino acid transporter (gpaat) subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in sodium-independent, high-affinity exchange of anionic amino acids with high specificity
  • for anionic form of cystine and glutamate
  • major genetic regulator of pheomelanin pigment in hair and melanocytes, with minimal or no effects on eumelanin, and controling the production of pheomelanin pigment
  • directly
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text cysteine/glutamate antiporter
    PATHWAY
    metabolism
    signaling
    a component
  • disulfide linked with SLC3A2/4F2HC
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS