Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC7A10 contributors: npt/ - updated : 01-09-2005
HGNC name solute carrier family 7, (cationic amino acid transporter, y+ system) member 10
HGNC id 11058
Location 19q12-q13.1      Physical location : 33.699.569 - 33.716.756
Synonym name
  • Asc-type aminoacid transporter 1
  • brain Na(+)-independent transporter for small nautral aminoacids (D-serine)
  • Synonym symbol(s) asc-1, ASC1, FLJ20839
    DNA
    TYPE functioning gene
    STRUCTURE 17.14 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1918 56.7 523 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Nervousbrain   highly
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • two conserved cysteine residues between TM3 and TM4, the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Asc1
    intraspecies homolog to LAT2
    Homologene
    FAMILY
  • solute carrier family 7
  • amino acid-polyamine-organocation (APC) superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane
    basic FUNCTION
  • transport of small neutral amino acids including the D isomers, in particular D-serine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein 4F2hc/CD98 (MDU1) at the basolateral membrane to form a complex mediating y(+)L-type transporter
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene cystinuria
    Marker
    Therapy target
    ANIMAL & CELL MODELS