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FLASH GENE
Symbol SLC6A13 contributors: - updated : 22-08-2007
HGNC name solute carrier family 6 (neurotransmitter transporter, GABA), member 13
HGNC id 11046
Location 12p13.3      Physical location : 329.788 - 372.039
Synonym name GABA transport protein
Synonym symbol(s) GAT2, GAT-2
DNA
TYPE functioning gene
STRUCTURE 42.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC30156 12p13.33 hypothetical protein MGC30156 KIAA1110 12p13.33 hypothetical protein MGC30156 SLC6A12 12p13 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 SLC6A13 12p13.3 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 RBBP2 12p11 retinoblastoma binding protein 2 MGC13183 12p13.33 hypothetical protein MGC13183 LOC390279 12 similar to proline-rich protein B4GalNac-T3 12p13.33 beta 1,4-N-acetylgalactosaminyltransferase-transferase-III NINJ2 12p13 ninjurin 2 PRKWNK1 12p13.3 protein kinase, lysine deficient 1 RAD52 12p13.33 RAD52 homolog (S. cerevisiae) ELKS 12p13.3 RAD52 homolog (S. cerevisiae) MGC40195 WNT5B 12p13.3 wingless-type MMTV integration site family, member 5B ADIPOR2 12p13.31 adiponectin receptor 2 CACNA2D4 12p13.33 calcium channel, voltage-dependent, alpha 2/delta subunit 4 DCP1B 12p13.33 decapping enzyme hDcp1b CACNA1C 12p13.33 calcium channel, voltage-dependent, L type, alpha 1C subunit FLJ11117 12p13.33 hypothetical protein FLJ11117 LOC283440 12p13.33 hypothetical LOC283440 LOC341511 12p13.33 similar to 60S ribosomal protein L23a FKBP4 12p13.33 FK506 binding protein 4, 59kDa MDS028 12p13.33 uncharacterized hematopoietic stem/progenitor cells protein MDS028 NRIP2 12p13.33 nuclear receptor interacting protein 2 FOXM1 12p13 forkhead box M1 MGC13204 12p13.33 hypothetical protein MGC13204 TULP3 12p13 tubby like protein 3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
 nervecranial nerve   
Respiratoryrespiratory tractlarynx   
Urinarykidney    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Slc6a13
ortholog to 91p100 identity to the mouse and rat orthologs mGAT3 and rGAT-2
Homologene
FAMILY sodium, neurotransmitter symporter (SNF) family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
text integral membrane protein
basic FUNCTION
  • terminating the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals
  • playing a role in maturation of the central nervous system, regulation of GABA levels in the cerebrospinal fluid, and a role in tight junctions in the kidney
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS