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FLASH GENE

Symbol

SLC6A11

contributors: mct/npt - updated : 12-12-2009

HGNC name	solute carrier family 6 (neurotransmitter transporter, GABA), member 11
HGNC id	11044

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p25.3      Physical location : 10.857.916 - 10.980.144
Synonym name	GABA-A transporter 4
Synonym symbol(s)	GAT4, GABT4, GABT3, GAT3

DNA

TYPE	functioning gene
STRUCTURE	122.23 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014229 14 - 1991 NP_055044 - 632 - Borden (1994)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus       brain midbrain       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous dopaminergic neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Slc6a11
	homolog to murine Gabt4

Homologene

FAMILY

sodium, neurotransmitter symporter (SNF) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral membrane protein

basic FUNCTION	terminating the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals
	may be involved in genetic susceptibility to treatment-resistant neuroleptic-induced tardive dyskinesia , at least in a subgroup of patients with schizophrenia (Inada 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

zinc, playing a role in modulating the balance between excitatory and inhibitory synaptic transmission

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS