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FLASH GENE
Symbol SLC5A2 contributors: mlc/npt - updated : 02-12-2011
HGNC name solute carrier family 5 (sodium/glucose cotransporter), member 2
HGNC id 11037
Corresponding disease
GLYS1 glycosuria renal 1
Location 16p11.2      Physical location : 31.494.438 - 31.502.092
Synonym name
  • sodium/glucose cotransporter 2
  • low affinity sodium-glucose cotransporter
  • solute carrier family 5 member 2
  • Synonym symbol(s) SGLT2, SL52, Na
    DNA
    TYPE functioning gene
    STRUCTURE 7.65 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2279 73 672 - 2004 14614622
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Endocrineadrenal gland    
     pancreas    
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    urinarykidney   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments protein (12TM)
  • cytoplasmic N and C termini
  • HOMOLOGY
    interspecies homolog to murine Slc5a2
    intraspecies homolog to SGLT1
    Homologene
    FAMILY
  • solute carrier family 5, sodium/glucose
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the glucose reabsorption in the kidney (in the early proximal convoluted tubule)
  • responsible for the bulk of glucose reabsorption in the kidney proximal convoluted tubule
  • potential role of its genetic variation in the regulation of glucose homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GLYS1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer with metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    SLC5A2 inhibition ias a viable insulin-independent treatment of type 2 diabetes
    ANIMAL & CELL MODELS